Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

XPC

  • Official Full Name

    xeroderma pigmentosum, complementation group C

  • Overview

    XPC is a component of the nucleotide excision repair (NER) pathway. XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age.
  • Synonyms

    XPC; xeroderma pigmentosum, complementation group C; DNA repair protein complementing XP-C cells; RAD4; xeroderma pigmentosum group C protein; XPCC; p125; mutant xeroderma pigmentosum group C; XP3;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XPC-848H Recombinant Human XPC Protein (496-734 aa), His-tagged E.coli His 496-734 aa
Mouse XPC-18626M Recombinant Mouse XPC Protein Mammalian Cell His
Mouse XPC-10233M Recombinant Mouse XPC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse XPC-10233M-B Recombinant Mouse XPC Protein Pre-coupled Magnetic Beads HEK293
Zebrafish XPC-4231Z Recombinant Zebrafish XPC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XPC Related Articles

XPC involved in several pathways and played different roles in them. We selected most pathways XPC participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nucleotide excision repairYY1A;COPS3;INO80B;POLE4;RAD23AB;RFC4;BIVM-ERCC5;COPS5;RFC3

XPC has several biochemical functions, for example, DNA binding, damaged DNA binding, single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPC itself. We selected most functions XPC had, and list some proteins which have the same functions with XPC. You can find most of the proteins on our site.

Function Related Protein
DNA bindingGTF2IRD1;PPARD;NKX6.3;H2AFJ;NUP153;TBX1;RARB;GATA3;ZNF71
damaged DNA bindingCREBBP;APEX1;BRCA1;POLI;ERCC1;DCLRE1A;RAD23AB;TP53BP1;TP73
single-stranded DNA bindingRTF1;CNBPA;HMGB1;PCBP1;NABP1A;XRCC2;CTC1;BRCA2;RAD51D

XPC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPC here. Most of them are supplied by our site. Hope this information will be useful for your research of XPC.

Pou5f1; Rad23b; Ywhae

Dreze, M; Calkins, AS; et al. Monitoring Repair of UV-Induced 6-4-Photoproducts with a Purified DDB2 Protein Complex. PLOS ONE 9:-(2014).
Bai, XF; Jin, F; et al. Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients. MEDICAL ONCOLOGY 29:1543-1553(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
In which cells or tissues is XPC expression most prominent? 05/09/2022

XPC is expressed ubiquitously but is especially important in skin cells exposed to UV radiation.

What is the primary role of XPC in DNA repair? 11/28/2020

XPC plays a crucial role in nucleotide excision repair (NER), recognizing and initiating repair of bulky DNA lesions.

Are there known genetic mutations in XPC linked to specific diseases? 08/15/2020

Genetic mutations in XPC are linked to Xeroderma Pigmentosum, a condition with extreme sensitivity to UV radiation and a high risk of skin cancers.

How is XPC dysfunction related to cancer development? 07/14/2020

Dysfunction in XPC can lead to an increased risk of skin cancers and other malignancies.

How does XPC contribute to maintaining genomic stability? 01/28/2020

By facilitating DNA repair, XPC helps maintain genomic stability and prevent mutations.

What is the relationship between XPC and UV radiation damage? 10/18/2019

XPC is vital for repairing UV-induced DNA damage, preventing mutations and skin cancers.

What therapeutic strategies are being explored involving XPC for disease prevention or treatment? 01/01/2019

Therapeutic strategies are focused on enhancing DNA repair mechanisms and preventing UV-induced skin damage.

Customer Reviews (3)

Write a review
Reviews
08/10/2022

    High-quality, perfect for experiments.

    06/18/2022

      Consistent and reliable results.

      03/16/2021

        Quick delivery, very satisfied.

        Ask a Question for All XPC Products

        Required fields are marked with *

        My Review for All XPC Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends