XPO5
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Official Full Name
exportin 5
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Overview
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. -
Synonyms
XPO5; exportin 5; exportin-5; KIAA1291; Exp 5; Exp5; Exportin5; FLJ14239; FLJ32057; FLJ45606; OTTHUMP00000016472; Ran binding protein 21; Ran-binding protein 21; Ranbp 21; Ranbp21; Xpo 5; XPO5_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- XPO5 Related Articles
XPO5 involved in several pathways and played different roles in them. We selected most pathways XPO5 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
RNA transport | SMN2;CLNS1A;THOC4;UPF3B;NUP37;UBE2I;ALYREF;PABPC1B;SUMO4 |
XPO5 has several biochemical functions, for example, RNA binding, Ran GTPase binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO5 itself. We selected most functions XPO5 had, and list some proteins which have the same functions with XPO5. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
RNA binding | CNP;TIAL1;RBM39B;DDX51;PUSL1;RBMS1;DHX36;NUFIP2;APOBEC2 |
Ran GTPase binding | XPO4;KPNB1;IPO4;IPO5;CSE1L;XPO6;RANGAP1;NUTF2;DPY19L2 |
mRNA binding | FXR1;XPO5;IGF2BP1;LUC7L3;RBFOX2;NXF3;RPS2;TRA2B;RBFOX1L |
poly(A) RNA binding | TRMT1L;SLIRP;Cstb;EMG1;WDR46;RBBP6;SRSF12;CELF2;PUF60 |
pre-miRNA binding | TARBP2;DICER1;XPO5 |
contributes_to pre-miRNA binding | XPO5;DICER1;TARBP2;RAN |
protein binding | TSTD2;CLEC4G;PLD3;PDS5A;NLRC4;PCTP;KCNA2;URM1;PGBD1 |
protein transporter activity | RANBP6;XPO5;RUFY1;AP1G2;XPO6;PGAP2;KPNA1;DSCR3;AP1S3A |
tRNA binding | MADD;IGHMBP2;FARS2;YARS2;EIF2A;TRNT1;MARS;METTL1;FARSA |
XPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO5.
pre-let-7a-1; MYC; vpu; Dlg4; PTP4A3; TNFRSF1B; MAGEA6; ARF6; RAN; CCNA1; FADD; SERINC3; IKBKE; TSC22D1; NEK6
- Q&As
- Reviews
Q&As (5)
Ask a questionTargeting XPO5 for cancer therapy involves the development of small molecule inhibitors that can disrupt its function, potentially leading to the suppression of tumor growth.
XPO5 protein plays a role in the export of specific microRNAs that can modulate immune responses, suggesting its involvement in immune-related diseases and therapies.
Research suggests that dysregulation of XPO5 protein expression may serve as a potential biomarker for certain diseases, including cancer and cardiovascular disorders.
Currently, there are ongoing clinical trials investigating the efficacy of XPO5 inhibitors in the treatment of certain types of cancer and other diseases.
XPO5 protein has been found to regulate the export of specific microRNAs that are involved in neuronal development and function, suggesting its potential involvement in neurological disorders.
Customer Reviews (3)
Write a reviewThe XPO5 protein comes highly recommended for its excellent performance in various research applications.
Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.
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