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XPO5

  • Official Full Name

    exportin 5

  • Overview

    This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
  • Synonyms

    XPO5; exportin 5; exportin-5; KIAA1291; Exp 5; Exp5; Exportin5; FLJ14239; FLJ32057; FLJ45606; OTTHUMP00000016472; Ran binding protein 21; Ran-binding protein 21; Ranbp 21; Ranbp21; Xpo 5; XPO5_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XPO5-1404H Recombinant Human XPO5 protein, His & T7-tagged E.coli His/T7 Ala2~Gln180 (Accession # Q9HAV4)
Human XPO5-1938HCL Recombinant Human XPO5 cell lysate N/A
Human XPO5-2819H Recombinant Human XPO5 protein, His-tagged E.coli His 1-100 aa
Human XPO5-2368H Recombinant Human XPO5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human XPO5-1794HFL Recombinant Full Length Human XPO5 Protein, C-Flag-tagged Mammalian cells Flag
Human XPO5-1405H Recombinant Human XPO5 protein, Myc/DDK-tagged HEK293T Myc/DDK
Human XPO5-2368H-B Recombinant Human XPO5 Protein Pre-coupled Magnetic Beads HEK293
Human XPO5-397H Recombinant Human XPO5 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human XPO5-6081H Recombinant Human XPO5 Protein (Ala2-Gln180), N-His tagged E.coli N-His Ala2-Gln180
Mouse XPO5-18631M Recombinant Mouse XPO5 Protein Mammalian Cell His
Mouse XPO5-10236M Recombinant Mouse XPO5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse XPO5-10236M-B Recombinant Mouse XPO5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque XPO5-5231R Recombinant Rhesus monkey XPO5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque XPO5-5044R-B Recombinant Rhesus Macaque XPO5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque XPO5-5044R Recombinant Rhesus Macaque XPO5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken XPO5-5030C Recombinant Chicken XPO5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XPO5 Related Articles

XPO5 involved in several pathways and played different roles in them. We selected most pathways XPO5 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportSMN2;CLNS1A;THOC4;UPF3B;NUP37;UBE2I;ALYREF;PABPC1B;SUMO4

XPO5 has several biochemical functions, for example, RNA binding, Ran GTPase binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO5 itself. We selected most functions XPO5 had, and list some proteins which have the same functions with XPO5. You can find most of the proteins on our site.

Function Related Protein
RNA bindingCNP;TIAL1;RBM39B;DDX51;PUSL1;RBMS1;DHX36;NUFIP2;APOBEC2
Ran GTPase bindingXPO4;KPNB1;IPO4;IPO5;CSE1L;XPO6;RANGAP1;NUTF2;DPY19L2
mRNA bindingFXR1;XPO5;IGF2BP1;LUC7L3;RBFOX2;NXF3;RPS2;TRA2B;RBFOX1L
poly(A) RNA bindingTRMT1L;SLIRP;Cstb;EMG1;WDR46;RBBP6;SRSF12;CELF2;PUF60
pre-miRNA bindingTARBP2;DICER1;XPO5
contributes_to pre-miRNA bindingXPO5;DICER1;TARBP2;RAN
protein bindingTSTD2;CLEC4G;PLD3;PDS5A;NLRC4;PCTP;KCNA2;URM1;PGBD1
protein transporter activityRANBP6;XPO5;RUFY1;AP1G2;XPO6;PGAP2;KPNA1;DSCR3;AP1S3A
tRNA bindingMADD;IGHMBP2;FARS2;YARS2;EIF2A;TRNT1;MARS;METTL1;FARSA

XPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO5.

pre-let-7a-1; MYC; vpu; Dlg4; PTP4A3; TNFRSF1B; MAGEA6; ARF6; RAN; CCNA1; FADD; SERINC3; IKBKE; TSC22D1; NEK6

Khacho, M; Mekhail, K; et al. eEF1A Is a Novel Component of the Mammalian Nuclear Protein Export Machinery. MOLECULAR BIOLOGY OF THE CELL 19:5296-5308(2008).
Kurihara, Y; Kawamura, Y; et al. Maintenance of genomic methylation patterns during preimplantation development require's the somatic form of DNA methyltransferase 1. DEVELOPMENTAL BIOLOGY 313:335-346(2008).
  • Q&As
  • Reviews

Q&As (5)

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How can XPO5 protein be targeted for cancer therapy? 05/16/2020

Targeting XPO5 for cancer therapy involves the development of small molecule inhibitors that can disrupt its function, potentially leading to the suppression of tumor growth.

How is XPO5 protein involved in the regulation of immune responses? 10/17/2019

XPO5 protein plays a role in the export of specific microRNAs that can modulate immune responses, suggesting its involvement in immune-related diseases and therapies.

Can XPO5 protein be used as a biomarker for disease diagnosis? 01/11/2017

Research suggests that dysregulation of XPO5 protein expression may serve as a potential biomarker for certain diseases, including cancer and cardiovascular disorders.

Are there any clinical trials targeting XPO5 protein? 04/30/2016

Currently, there are ongoing clinical trials investigating the efficacy of XPO5 inhibitors in the treatment of certain types of cancer and other diseases.

How is XPO5 protein related to neurological disorders? 03/18/2016

XPO5 protein has been found to regulate the export of specific microRNAs that are involved in neuronal development and function, suggesting its potential involvement in neurological disorders.

Customer Reviews (3)

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Reviews
11/05/2019

    The XPO5 protein comes highly recommended for its excellent performance in various research applications.

    09/08/2019

      Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

      04/03/2019

        It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.

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