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XPOT

  • Official Full Name

    exportin, tRNA (nuclear export receptor for tRNAs)

  • Overview

    This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.
  • Synonyms

    XPOT; exportin, tRNA (nuclear export receptor for tRNAs); exportin-T; XPO3; AI452076; C79645; 1110004L07Rik; 3110065H13Rik; Exportin tRNA; tRNA exportin; exportin(tRNA);

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XPOT-1939HCL Recombinant Human XPOT cell lysate N/A
Rat Xpot-595R Recombinant Rat Xpot Protein, His-tagged E.coli N-His Met1-Lys269
Rhesus Macaque XPOT-5232R Recombinant Rhesus monkey XPOT Protein, His-tagged Mammalian Cell His
Rhesus Macaque XPOT-5045R Recombinant Rhesus Macaque XPOT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque XPOT-5045R-B Recombinant Rhesus Macaque XPOT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish XPOT-3974Z Recombinant Zebrafish XPOT Mammalian Cell His
Chicken XPOT-4418C Recombinant Chicken XPOT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XPOT Related Articles

XPOT involved in several pathways and played different roles in them. We selected most pathways XPOT participated on our site, such as Gene Expression, RNA transport, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPOT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionZNF785;ZNF688;CTDP1;ZIM2;POU2F1;OSGEP;NRBF2B;ZFP143;POLR3GLA
RNA transportSUMO3;FMR1;NCBP2;TPR;NUP88;RPP40;POP7;NUP160;EIF3JA
tRNA processingTRMT61A;QTRTD1;METTL1;LCMT2;TRMT5;ALKBH8;PUS7;FAM98B;POP1
tRNA processing in the nucleusPOP7;C2orf49;RPP40;C22orf28;FAM98B;POP1;TSEN15;POP4;TSEN54

XPOT has several biochemical functions, for example, Ran GTPase binding, nucleobase-containing compound transmembrane transporter activity, tRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPOT itself. We selected most functions XPOT had, and list some proteins which have the same functions with XPOT. You can find most of the proteins on our site.

Function Related Protein
Ran GTPase bindingRANBP1;XPO7;IPO5;XPO6;RANBP3;KPNB1;IPO11;RANBP2;RANGAP1
nucleobase-containing compound transmembrane transporter activity
tRNA bindingEIF2A;CARS;EIF2AK4;SEPSECS;FARSA;DARS2;XPOT;CTU2;MARS

XPOT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPOT here. Most of them are supplied by our site. Hope this information will be useful for your research of XPOT.

TNFRSF1A; TNFRSF1B; CLN3; CAMKK2; MAP3K3; Dnaaf5; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; EGFR; MYC; XRCC1; RAN; IQCB1; Hsph1; ARMC6; P

Khacho, M; Mekhail, K; et al. eEF1A Is a Novel Component of the Mammalian Nuclear Protein Export Machinery. MOLECULAR BIOLOGY OF THE CELL 19:5296-5308(2008).
Bohnsack, MT; Czaplinski, K; et al. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA-A PUBLICATION OF THE RNA SOCIETY 10:185-191(2004).
Arts, GJ; Kuersten, S; et al. The role of exportin-t in selective nuclear export of mature tRNAs. EMBO JOURNAL 17:7430-7441(1998).
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