YBX1
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Official Full Name
Y box binding protein 1
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Overview
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.<br/>The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. -
Synonyms
YBX1; Y box binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- YBX1 Related Articles
YBX1 involved in several pathways and played different roles in them. We selected most pathways YBX1 participated on our site, such as BDNF signaling pathway, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with YBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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BDNF signaling pathway | CDKL5;CDK5;LINGO1;EIF4EBP1;DPYSL2;EIF4E;CFL1;GNB2L1;CSNK2A1 |
Gene Expression | NR5A1B;ALKBH8;ZNF771;ZNF530;CLP1;ZNF498;SMG8;HNRPL;FAM98B |
Processing of Capped Intron-Containing Pre-mRNA | ZCRB1;HNRNPA0L;CSTF3;SF3B2;CSTF1;WTAP;RBM5;METTL3;SNRNP48 |
SIDS Susceptibility Pathways | FOXM1;KCNJ8;PHOX2B;RUNX3;ASCL1;SCN3B;CHRFAM7A;POU2F2;IL1RN |
Signaling events mediated by PTP1B | NOX4;YBX1;CSN2;DOK1 |
mRNA Splicing | RBM5;HNRNPL;SNRNP25;HNRNPUL1;HNRPL;ZMAT5;HNRNPA2B1;SF3B2;CCAR1 |
mRNA Splicing - Major Pathway | PTBP1;CCAR1;DNAJC8;TXNL4A;HNRNPL;HNRPL;SFRS3A;SUGP1;HNRNPA2B1 |
mRNA Splicing - Minor Pathway | SNRNP35;RNPC3;ZMAT5;SNRNP25;SF3B2;ZCRB1;YBX1;SNRNP48;TXNL4A |
YBX1 has several biochemical functions, for example, DNA binding, GTPase binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YBX1 itself. We selected most functions YBX1 had, and list some proteins which have the same functions with YBX1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | OASL1;PTGES2;ZNF69;ZNF484;ZNF668;POLA1;AIFM1;RBM6;PAX2A |
GTPase binding | GNB1;LCP1;AIMP1;IARS;ENO1;GNB2;GNB3;SPTBN1;MARCH5 |
RNA binding | PCBP4;RPL19;AGFG1;EWSR1;DDX11;HNRNPA0;DPPA5A;SCAF1;SMN2 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | MEIS1;TBX15;EBF1;FOXK2;PITX3;MAFB;CTCFL;ESR1;GCM1 |
chromatin binding | MNT;ATF5;MAZ;TSHZ3;PRKCBB;CCNT1;C19orf40;CBX5;RUNX2 |
double-stranded DNA binding | PIN4;AIM2;HMGB1;ERCC5;KIN;SATB1;HNRNPDL;PRKDC;TDP1 |
poly(A) RNA binding | KRR1;FXR1;SARS2;ATXN2L;CDC42EP4;PDAP1;HNRNPDL;PABPC1;MRPS26 |
protein binding | EDAR;TAGLN;VARS;GPR125;ISOC1;CHAC1;U2AF1;ARSI;RPP30 |
single-stranded DNA binding | RAD23A;OBFC2B;PURB;CNBP;SETMAR;HNRPDL;NEIL3;WBP11;SUB1 |
transcription factor activity, sequence-specific DNA binding | NEUROG1;HOXD4A;CITED1;ZNF691;ZKSCAN6;RFX3;ZSCAN16;ESRRGA;ZNF454 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PAX5;ONECUT1;GLI3;MEF2A;KLF4;NRF1;EBF4;SP1;TLX1 |
YBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YBX1.
SYNCRIP; C1QBP; HNRNPR; DHX9
- Q&As
- Reviews
Q&As (7)
Ask a questionAltered YBX1 activity is linked with the progression of various cancers due to its role in regulating gene expression.
It plays a key role in stabilizing mRNA, influencing the translation and stability of specific transcripts.
Targeting YBX1 could offer new strategies for cancer treatment by influencing key pathways in tumor cells.
YBX1 is important for gene regulation, modulating the expression of numerous genes.
YBX1, a multifunctional RNA-binding protein, is involved in various aspects of RNA metabolism and regulation.
Genetic mutations in YBX1 can lead to dysregulated RNA processing and gene expression, affecting overall cell function.
YBX1 interacts with a variety of nucleic acid-binding proteins, playing a role in the complex regulation of RNA.
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