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YBX1

  • Official Full Name

    Y box binding protein 1

  • Overview

    Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.<br/>The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
  • Synonyms

    YBX1; Y box binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human YBX1-3763H Recombinant Human YBX1, GST-tagged E.coli GST C-191aa
Human YBX1-636H Recombinant Human Y box binding protein 1, His-tagged E.coli His
Human YBX1-4839H Recombinant Human YBX1, GST-tagged Wheat Germ GST
Human YBX1-30136TH Recombinant Human YBX1, His-tagged E.coli His
Human YBX1-4838H Recombinant Human YBX1, GST-tagged Wheat Germ GST
Human YBX1-6926H Recombinant Human YBX1, MYC/DDK-tagged HEK293 Myc/DDK
Human YBX1-1945HCL Recombinant Human YBX1 cell lysate N/A
Human YBX1-553HF Recombinant Full Length Human YBX1 Protein, GST-tagged In Vitro Cell Free System GST 324 amino acids
Human YBX1-4852H Recombinant Human YBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YBX1-3540HFL Recombinant Full Length Human YBX1, Flag-tagged Mamanlian cells Flag
Human YBX1-637H Recombinant Human YBX1 protein, His-tagged E.coli His Gln134~Glu324
Mouse YBX1-18652M Recombinant Mouse YBX1 Protein Mammalian Cell His
Mouse YBX1-10250M Recombinant Mouse YBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ybx1-7029M Recombinant Mouse Ybx1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse YBX1-10250M-B Recombinant Mouse YBX1 Protein Pre-coupled Magnetic Beads HEK293
Mouse YBX1-1557M Recombinant Mouse YBX1 Protein (2-322 aa), His-tagged Yeast His 2-322 aa
Rat YBX1-6625R Recombinant Rat YBX1 Protein Mammalian Cell His
Rat YBX1-6281R-B Recombinant Rat YBX1 Protein Pre-coupled Magnetic Beads HEK293
Rat YBX1-6281R Recombinant Rat YBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish YBX1-6756Z Recombinant Zebrafish YBX1 Mammalian Cell His
Chicken YBX1-5984C Recombinant Chicken YBX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • YBX1 Related Articles

YBX1 involved in several pathways and played different roles in them. We selected most pathways YBX1 participated on our site, such as BDNF signaling pathway, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with YBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayCDKL5;CDK5;LINGO1;EIF4EBP1;DPYSL2;EIF4E;CFL1;GNB2L1;CSNK2A1
Gene ExpressionNR5A1B;ALKBH8;ZNF771;ZNF530;CLP1;ZNF498;SMG8;HNRPL;FAM98B
Processing of Capped Intron-Containing Pre-mRNAZCRB1;HNRNPA0L;CSTF3;SF3B2;CSTF1;WTAP;RBM5;METTL3;SNRNP48
SIDS Susceptibility PathwaysFOXM1;KCNJ8;PHOX2B;RUNX3;ASCL1;SCN3B;CHRFAM7A;POU2F2;IL1RN
Signaling events mediated by PTP1BNOX4;YBX1;CSN2;DOK1
mRNA SplicingRBM5;HNRNPL;SNRNP25;HNRNPUL1;HNRPL;ZMAT5;HNRNPA2B1;SF3B2;CCAR1
mRNA Splicing - Major PathwayPTBP1;CCAR1;DNAJC8;TXNL4A;HNRNPL;HNRPL;SFRS3A;SUGP1;HNRNPA2B1
mRNA Splicing - Minor PathwaySNRNP35;RNPC3;ZMAT5;SNRNP25;SF3B2;ZCRB1;YBX1;SNRNP48;TXNL4A

YBX1 has several biochemical functions, for example, DNA binding, GTPase binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YBX1 itself. We selected most functions YBX1 had, and list some proteins which have the same functions with YBX1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingOASL1;PTGES2;ZNF69;ZNF484;ZNF668;POLA1;AIFM1;RBM6;PAX2A
GTPase bindingGNB1;LCP1;AIMP1;IARS;ENO1;GNB2;GNB3;SPTBN1;MARCH5
RNA bindingPCBP4;RPL19;AGFG1;EWSR1;DDX11;HNRNPA0;DPPA5A;SCAF1;SMN2
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMEIS1;TBX15;EBF1;FOXK2;PITX3;MAFB;CTCFL;ESR1;GCM1
chromatin bindingMNT;ATF5;MAZ;TSHZ3;PRKCBB;CCNT1;C19orf40;CBX5;RUNX2
double-stranded DNA bindingPIN4;AIM2;HMGB1;ERCC5;KIN;SATB1;HNRNPDL;PRKDC;TDP1
poly(A) RNA bindingKRR1;FXR1;SARS2;ATXN2L;CDC42EP4;PDAP1;HNRNPDL;PABPC1;MRPS26
protein bindingEDAR;TAGLN;VARS;GPR125;ISOC1;CHAC1;U2AF1;ARSI;RPP30
single-stranded DNA bindingRAD23A;OBFC2B;PURB;CNBP;SETMAR;HNRPDL;NEIL3;WBP11;SUB1
transcription factor activity, sequence-specific DNA bindingNEUROG1;HOXD4A;CITED1;ZNF691;ZKSCAN6;RFX3;ZSCAN16;ESRRGA;ZNF454
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPAX5;ONECUT1;GLI3;MEF2A;KLF4;NRF1;EBF4;SP1;TLX1

YBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YBX1.

SYNCRIP; C1QBP; HNRNPR; DHX9

Blackwell, E; Ceman, S; et al. A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein. JOURNAL OF CELL SCIENCE 124:3060-3065(2011).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of altered YBX1 activity on cancer development? 06/23/2023

Altered YBX1 activity is linked with the progression of various cancers due to its role in regulating gene expression.

How does YBX1 contribute to mRNA stabilization? 06/08/2023

It plays a key role in stabilizing mRNA, influencing the translation and stability of specific transcripts.

What potential therapeutic applications arise from targeting YBX1 in diseases like cancer? 05/22/2022

Targeting YBX1 could offer new strategies for cancer treatment by influencing key pathways in tumor cells.

What role does YBX1 play in gene regulation? 02/08/2022

YBX1 is important for gene regulation, modulating the expression of numerous genes.

What is the primary role of YBX1 in cellular processes? 02/18/2021

YBX1, a multifunctional RNA-binding protein, is involved in various aspects of RNA metabolism and regulation.

How do genetic variations in YBX1 affect cellular functions? 10/02/2018

Genetic mutations in YBX1 can lead to dysregulated RNA processing and gene expression, affecting overall cell function.

How does YBX1 interact with other nucleic acid-binding proteins? 03/26/2018

YBX1 interacts with a variety of nucleic acid-binding proteins, playing a role in the complex regulation of RNA.

Customer Reviews (3)

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05/10/2022

    Trustworthy results, a key component of our research.

    12/27/2020

      Swift and accurate service, highly trusted in research.

      03/14/2017

        Invaluable support for insights, boosts research efficiency.

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