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ZAK

Official Full Name

sterile alpha motif and leucine zipper containing kinase AZK
Overview

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms

ZAK; sterile alpha motif and leucine zipper containing kinase AZK; mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZAK-1510H	Active Recombinant Human ZAK, GST-tagged	Sf9 Insect Cell	GST	Full length	Inquiry
Human	ZAK-457H	Recombinant Human ZAK, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	ZAK-224HCL	Recombinant Human ZAK 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ZAK involved in several pathways and played different roles in them. We selected most pathways ZAK participated on our site, such as MAPK signaling pathway, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZAK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	AKT1;BRAF;Pdgfa&Pdgfb;PAK2A;FGF1B;MAPK3;TGFB3;NFKB2;PPM1NB
Tight junction	F11R;SHROOM1;CLDNC;VMHCL;MYH9;MYLPF;HCLS1;RAB13;GNAI3

ZAK has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZAK itself. We selected most functions ZAK had, and list some proteins which have the same functions with ZAK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TRPM6;ATP6V1BA;MLH1;TLK2;CMPK2;ABCC10;STK25;TXK;KIF27
MAP kinase kinase kinase activity	MAP3K12;STK3;TAOK1;ZAK;MAP3K8;MAP3K13;MAP3K5;MOS;MAP3K14
magnesium ion binding	MAST2;PGM2;GTPBP5;NLRC4;ADSS;TSSK6;ENOPH1;ALPI;STK4
poly(A) RNA binding	RBM4;PUS1;NOL6;EIF1;CDKN2A;RCC2;CPSF6;ACTN4;ZC3H11A
protein binding	TBC1D1;NVL;CDC14B;IRF3;CEP290;NMRK2;DSC2;WT1;ITGB4
protein serine/threonine kinase activity	DYRK1A;MAPK1;ZNF143B;GSK3B;TAOK1;STK32B;PRKG1A;STK32A;PRKDC

ZAK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZAK here. Most of them are supplied by our site. Hope this information will be useful for your research of ZAK.