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ZBTB33

Official Full Name

zinc finger and BTB domain containing 33
Overview

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-&#945;2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Synonyms

ZBTB33; zinc finger and BTB domain containing 33; transcriptional regulator Kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF kaiso; ZNF348; Kaiso protein; Kaiso transcription factor; KAISO_HUMAN; ZBTB 33; Zinc finger and BTB domain-containing protein 33; Zinc finger transcription factor Kaiso; ZNF 348; OTTHUMP00000023933; OTTHUMP00000245265; ZNF-kaiso;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZBTB33-1954HCL	Recombinant Human ZBTB33 cell lysate		N/A		Inquiry
Human	ZBTB33-220H	Recombinant Human ZBTB33 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ZBTB33-6851HF	Recombinant Full Length Human ZBTB33 Protein, GST-tagged	In Vitro Cell Free System	GST	673 amino acids	Inquiry
Rhesus Macaque	ZBTB33-5258R	Recombinant Rhesus monkey ZBTB33 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ZBTB33-5071R	Recombinant Rhesus Macaque ZBTB33 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	ZBTB33-5071R-B	Recombinant Rhesus Macaque ZBTB33 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ZBTB33-5815Z	Recombinant Zebrafish ZBTB33	Mammalian Cell	His		Inquiry
Chicken	ZBTB33-3562C	Recombinant Chicken ZBTB33	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ZBTB33 involved in several pathways and played different roles in them. We selected most pathways ZBTB33 participated on our site, such as Wnt Signaling Pathway and Pluripotency, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt Signaling Pathway and Pluripotency	FBXW2;FOXD3;ZBTB33;LRRK2;PPM1J

ZBTB33 has several biochemical functions, for example, metal ion binding, methyl-CpG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB33 itself. We selected most functions ZBTB33 had, and list some proteins which have the same functions with ZBTB33. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	MYOC;CSK;ZSCAN16;ZFP422;PPAT;RIOK1;ZC3H15;GALNTL6;ADK
methyl-CpG binding	MBD3;MBD3L1;ZBTB4;MBD1;ZNF295;MBD1B;UHRF1;MECP2;LRWD1
protein binding	MFAP4;OLIG3;FOXP2;TERT;KLF17;TRIP10;SMAD5;TRA2B;SSBP3
sequence-specific DNA binding	HOXC10A;POU2F1;ZNF500;ATF7A;HOXB3A;PRRX1B;CREMB;FOXJ2;BATF

ZBTB33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB33 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB33.

CTNND1; WDR48; q81sn0_bacan; AIM2; SF3B1; FOXM1; TRIML2; RNF169; TRMT10A; CCDC101; CLPTM1L; DPH7; KLF16; CCDC61