Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ZIC1

Official Full Name

Zic family member 1
Overview

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
Synonyms

ZIC1; Zic family member 1; ZIC; ZNF201; zinc finger protein ZIC 1; zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zic family member 1 (odd-paired homolog, Drosophila);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZIC1-31656TH	Recombinant Human ZIC1	Wheat Germ	N/A	94 amino acids	Inquiry
Human	ZIC1-440H	Recombinant Human ZIC1 Protein, His-tagged	E.coli	His		Inquiry
Mouse	ZIC1-19176M	Recombinant Mouse ZIC1 Protein	Mammalian Cell	His		Inquiry
Mouse	ZIC1-10379M-B	Recombinant Mouse ZIC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ZIC1-10379M	Recombinant Mouse ZIC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	ZIC1-8574Z	Recombinant Zebrafish ZIC1	Mammalian Cell	His		Inquiry
Chicken	ZIC1-5827C	Recombinant Chicken ZIC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ZIC1 Related Articles
ZIC1 Related Research Area

ZIC1 involved in several pathways and played different roles in them. We selected most pathways ZIC1 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neural Crest Differentiation	MIA;MBP;TBX6;TFAP2A;GBX2;HEY2;LHX1;DMBX1;CDH6

ZIC1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC1 itself. We selected most functions ZIC1 had, and list some proteins which have the same functions with ZIC1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	ATF3;MYB;ZBTB7A;KCNA3;NR3C1;NFATC4;MEF2B;FOXJ1;TP73
metal ion binding	AMY1A;ACSM4;CISD3;ZNF79;DPH3P1;BAK1;MICALL2B;AARSD1;CYP2X10.2
transcription factor activity, sequence-specific DNA binding	BACH1;ETV5B;INSM1B;HOXC6;TBX5;TRIM22;MYF6;RREB1;UBN1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	MYBL1;EBF3A;CREB3L2;CEBPE;GLI2;CEBPG;NKX2-8;OTX1;FIGLA

ZIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC1.

Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).

Degreef, I; De Smet, L; et al. Immunohistochemical evidence for Zic1 coexpression with -catenin in the myofibroblast of Dupuytren disease. SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY 43:36-40(2009).

Somite Markers

Neural Stem Cell Markers

Neural Stem Cell Transcription Factors

Adipogenesis Markers