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ZNRF1

Official Full Name

zinc and ring finger 1, E3 ubiquitin protein ligase
Overview

In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.
Synonyms

ZNRF1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger 1; E3 ubiquitin-protein ligase ZNRF1; DKFZp434E229; FLJ14846; nin283; nerve injury gene 283; zinc/RING finger protein 1; zinc and ring finger protein 1; nerve injury-induced;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZNRF1-134H	Recombinant Human ZNRF1, GST-tagged	E.coli	GST		Inquiry
Human	ZNRF1-443H	Recombinant Human ZNRF1 Protein, His-tagged	E.coli	His		Inquiry
Human	ZNRF1-3880H	Recombinant Human ZNRF1, His-tagged	E.coli	His	4-143aa	$319 / 25ug
Human	ZNRF1-2097HCL	Recombinant Human ZNRF1 cell lysate		N/A		Inquiry
Mouse	ZNRF1-19219M	Recombinant Mouse ZNRF1 Protein	Mammalian Cell	His		Inquiry
Mouse	ZNRF1-10491M-B	Recombinant Mouse ZNRF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ZNRF1-10491M	Recombinant Mouse ZNRF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	ZNRF1-5371R	Recombinant Rhesus monkey ZNRF1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ZNRF1-5184R-B	Recombinant Rhesus Macaque ZNRF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	ZNRF1-5184R	Recombinant Rhesus Macaque ZNRF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	ZNRF1-11118Z	Recombinant Zebrafish ZNRF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ZNRF1 Related Articles

ZNRF1 involved in several pathways and played different roles in them. We selected most pathways ZNRF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ZNRF1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNRF1 itself. We selected most functions ZNRF1 had, and list some proteins which have the same functions with ZNRF1. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	ZFP91;TMEM129;CDC34B;LIG4;HECTD3;RFWD3;HECW1;UBE2G1B;LRSAM1
protein binding	PIH1D1;CCDC135;ERAL1;SILV;MCM4;TAF7;DGCR8;ZNF365;UBA6
ubiquitin protein ligase activity	RNF19A;UBE2NA;HACE1;RFFL;UBE2KA;NEDD4;PDZD4;C18orf25;MDM2
ubiquitin-protein transferase activity	UBE2K;MDM2;UBE2N;RNF11;CBLB;TSPAN17;TRIM27;FBXL6;UBE2E1
zinc ion binding	CA4A;UPF1;AGBL4;LNX2A;RUFY1;TRIM42;ADH8B;ZFP330;MMP11

ZNRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNRF1.

UBE2D1; UBE2D2; UBE2E1; UBE2D3; UBE2N; UBE2D4

Stinton, LM; Myers, RP; et al. Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection. BMC GASTROENTEROLOGY 13:-(2013).

Xiong, R; Nie, L; et al. Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution. JOURNAL OF IMMUNOLOGY 188:2653-2668(2012).