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ZP3

  • Official Full Name

    zona pellucida glycoprotein 3 (sperm receptor)

  • Overview

    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    ZP3; zona pellucida glycoprotein 3 (sperm receptor); ZPC; ZP3A; ZP3B; Zp-3; zona pellucida sperm-binding protein 3; ZP3A/ZP3B; sperm receptor; zona pellucida protein C; zona pellucida glycoprotein 3B; zona pellucida glycoprotein ZP3; zona pellucida glycoprotein 3A (sperm receptor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ZP3-1055H Recombinant Human ZP3 Protein, His-tagged Mammalian cells His
Human ZP3-2099HCL Recombinant Human ZP3 cell lysate N/A
Human ZP3-3784H Recombinant Human ZP3 protein, His-SUMO-tagged E.coli His-SUMO 23-387aa
Human ZP3-0485H Recombinant Human ZP3 Protein (Gln23-Val387), N-His-tagged Baculovirus-Insect cells N-His Gln23-Val387
Human ZP3-4344H-B Recombinant Human ZP3 Protein Pre-coupled Magnetic Beads HEK293
Human ZP3-1275H Recombinant Human ZP3 Protein (23-346 aa), GST-tagged E.coli GST 23-346 aa
Human ZP3-6585H Recombinant Human ZP3 Protein (Gln23-Val387), C-His tagged Mammalian cells C-His Gln23-Val387
Human ZP3-4344H Recombinant Human ZP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ZP3-19225M Recombinant Mouse ZP3 Protein Mammalian Cell His
Mouse ZP3-10495M Recombinant Mouse ZP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ZP3-10495M-B Recombinant Mouse ZP3 Protein Pre-coupled Magnetic Beads HEK293
Rat ZP3-6716R Recombinant Rat ZP3 Protein Mammalian Cell His
Rat ZP3-6372R Recombinant Rat ZP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ZP3-6372R-B Recombinant Rat ZP3 Protein Pre-coupled Magnetic Beads HEK293
Gallus gallus (Chicken) RFL30192GF Recombinant Full Length Chicken Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length (21-360)
Mesocricetus auratus (Golden hamster) RFL11466MF Recombinant Full Length Mesocricetus Auratus Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-349)
Mus musculus (Mouse) RFL8385MF Recombinant Full Length Mouse Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-351)
Oryctolagus cuniculus (Rabbit) RFL15622OF Recombinant Full Length Rabbit Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-341)
Rattus norvegicus (Rat) RFL24160RF Recombinant Full Length Rat Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-351)
Sus scrofa (Pig) RFL15985SF Recombinant Full Length Pig Zona Pellucida Sperm-Binding Protein 3(Zp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-332)
Zebrafish ZP3-8918Z Recombinant Zebrafish ZP3 Mammalian Cell His
Chicken ZP3-5959C Recombinant Chicken ZP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ZP3 Related Articles

ZP3 involved in several pathways and played different roles in them. We selected most pathways ZP3 participated on our site, such as Fertilization, Interaction With The Zona Pellucida, Ovarian Infertility Genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FertilizationCATSPERG2;ADAM20;CATSPER2;CATSPER3;ZP2;OVGP1;ADAM2;Acr;IZUMO1
Interaction With The Zona PellucidaADAM21;OVGP1;ADAM20;ZP2;ZP3;ADAM2;ADAM30
Ovarian Infertility GenesNRIP1;DMC1;MSH5;SYNE2;INHA;GJA4;ZP2;ZP3;NR5A1
ReproductionCATSPER2;ADAM20;Acr;ADAM2;ZP3;CATSPERB;CATSPER3;OVGP1;ZP2

ZP3 has several biochemical functions, for example, acrosin binding, carbohydrate binding, manganese ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZP3 itself. We selected most functions ZP3 had, and list some proteins which have the same functions with ZP3. You can find most of the proteins on our site.

Function Related Protein
acrosin bindingSERPINA5;ZP2;ZP3
carbohydrate bindingFCN1;ZG16;ILLR4;ZG16B;ZP3;ATRN;LGALS3L;FCNA;CHI3L2
manganese ion transmembrane transporter activitySLC11A2;MMGT2;SLC11A1;ZP3;TRPM2
protein bindingTRAF3IP1;GTSE1;KRT5;KLHL3;MEGF6;PYY;CNO;NUP153;TMEM199
signal transducer activityVMN1R46;OPN4.1;DRD4A;TAS2R138;MTNR1AA;FZD1;GNGT2B;CXCR3.2;TAS2R109
store-operated calcium channel activityTRPC7A;TRPC3;TRPC1;ORAI1;TRPC2;TRPC6A;ZP3;TRPC5A;TRPC7

ZP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZP3.

Khosravi-Farsani, S; Amidi, F; et al. Isolation and Enrichment of Mouse Female Germ Line Stem Cells. CELL JOURNAL 16:406-415(2015).
Kongmanas, K; Kruevaisayawan, H; et al. Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Reveals Roles of Acrosomal Proteins in ZP3 Binding. JOURNAL OF CELLULAR PHYSIOLOGY 230:449-463(2015).
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