ZWINT
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Official Full Name
ZW10 interactor
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Overview
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ZWINT; ZW10 interactor; KNTC2AP; HZwint1; KNTC 2 AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZWINT 1; zwint-1; OTTHUMP00000019626; OTTHUMP00000019628; ZW10-interacting protein 1; human ZW10 interacting protein-1; ZWINT1; HZwint-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ZWINT involved in several pathways and played different roles in them. We selected most pathways ZWINT participated on our site, such as Cell Cycle, Mitotic, M Phase, Mitotic Anaphase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZWINT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | NUP50;KIF2B;BLZF1;CLASP1;NEK9;CDK11B;OFD1;GINS2;DULLARD |
| M Phase | WAPAL;NCAPH2;CNEP1R1;DULLARD;RCC2;SMC2;NEK6;NIPBLA;DSN1 |
| Mitotic Anaphase | CENPP;CENPN;ZW10;B9D2;CENPQ;CENPO;ITGB3BP;SPDL1;NDEL1A |
| Mitotic Metaphase and Anaphase | WAPAL;NDEL1A;SGOL1;ERCC6L;SPC24;B9D2;NDEL1;ZWILCH;CENPE |
| Mitotic Prometaphase | RCC2;CCDC99;SPC24;NDC80;NDEL1;CDCA8;SPC25;MLF1IP;ZW10 |
| RHO GTPase Effectors | ERCC6L;NSL1;IQGAP3;NDEL1A;RHOAE;WIPF3;PMF1;ACTR2B;RHOGA |
| RHO GTPases Activate Formins | NUF2;AHCTF1;SKA2;PMF1;EVL;RANGAP1B;CCDC99;MKL1B;ZWINT |
ZWINT has several biochemical functions, for example, protein N-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZWINT itself. We selected most functions ZWINT had, and list some proteins which have the same functions with ZWINT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | ZWINT;KCNIP1;TBL1XR1;STXBP1;SMARCE1;EIF5A;TSC1;EXOC4;TAF11 |
| protein binding | NDUFS7;CIRH1A;AGTRAP;HER5;BEND7;ADCY6;MRPL23;CCDC60;ALKBH6 |
ZWINT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZWINT here. Most of them are supplied by our site. Hope this information will be useful for your research of ZWINT.
NDC80; BECN1; MIS12
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