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AFP

  • Official Full Name

    alpha-fetoprotein

  • Overview

    This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
  • Synonyms

    AFP; alpha-fetoprotein; FETA; HPAFP; alpha-fetoglobulin; alpha-1-fetoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Aspergillus giganteus
  • Cattle
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human Cell
  • Human Cord Blood
  • Human Cord Serum
  • Human Fetal Cord Serum
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • B2M
  • HlgG1 Fc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AFP-4180H Purified Human Alpha-Fetoprotein Human N/A
Human AFP-225H Recombinant Human AFP, StrepII-tagged Human Cell Strep II 20-609, 590 a.a.
Human AFP-6858H Recombinant Human AFP, His tagged HEK293 His Met 1-Val 609
Human AFP-9461H Recombinant Human AFP, His-tagged E.coli His 260-609a.a.
Human AFP-29H Recombinant Human AFP protein, M2 Peptide fused E.coli N/A
Human AFP-48H Recombinant Human Alpha-Fetoprotein Yeast N/A
Human AFP-413H Recombinant Human AFP Protein, GST-tagged Wheat Germ GST
Human AFP-545H Recombinant Human AFP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AFP-4769H Human Alpha-Fetoprotein Human Cord Serum N/A
Human AFP-52H Recombinant Human AFP Protein, His-tagged Insect Cell His 19-609
Human AFP-120H Recombinant Human AFP Protein, His-tagged E.coli His Ile31~Pro171
Human AFP-121H Recombinant Human AFP Protein, His-tagged E.coli His Ile31~Ser576
Human AFP-1706HCL Recombinant Human AFP cell lysate Human Cell N/A
Human AFP-1059H Recombinant Human AFP Protein (Met1-Val609), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Val609
Human AFP-993HF Recombinant Full Length Human AFP Protein, GST-tagged In Vitro Cell Free System GST 609 amino acids
Human AFP-1180H Native Human Alpha-Fetoprotein Human Cord Blood N/A
Human AFP-3018P Native pig AFP Human Cord Serum N/A
Human AFP-1254H Active Recombinant Human AFP protein, His-tagged HEK293 His Arg19-Val609
Human AFP-289H Recombinant Human AFP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AFP-3017H Native Human fetal cord serum Human Fetal Cord Serum N/A 609
Human AFP-0455H Recombinant Human AFP Protein (Leu260-Val609), N-His-tagged E.coli N-His Leu260-Val609
Human AFP29291H Recombinant Human AFP Protein
Human AFP-8027H Native Human Alpha FetoProtein Human Cord Blood N/A
Human AFP-0004H Recombinant Human AFP Protein HEK293 cells
Human AFP-082H Recombinant Human AFP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human AFP-1950H Recombinant Human AFP protein, hFc-tagged HEK293 hFc Met1-Val609
Human AFP-1H Alfafoetoprotein (AFP) Reference Standard N/A
Human AFP-289H-B Recombinant Human AFP Protein Pre-coupled Magnetic Beads HEK293
Human AFP-488HFL Recombinant Full Length Human AFP Protein, C-Flag-tagged Mammalian cells Flag
Human AFP-0456H Recombinant Human AFP Protein (Met1-Val609), C-His-tagged Mammalian cells C-His Met1-Val609
Human AFP-412H Native Human AFP Protein Human N/A
Mouse AFP-1404M Recombinant Mouse AFP Protein Mammalian Cell His
Mouse Afp-3366M Recombinant Mouse Afp, His-tagged E.Coli or Yeast His 605
Mouse Afp-122M Recombinant Mouse Afp Protein, His-tagged E.coli His Lys399~Val605
Mouse Afp-2491M Recombinant Mouse Afp protein, N/A-tagged E.coli N/A 19-605aa
Mouse AFP-379M-B Recombinant Mouse AFP Protein Pre-coupled Magnetic Beads HEK293
Mouse Afp-552M Recombinant Mouse Afp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AFP-379M Recombinant Mouse AFP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Afp-5337M Recombinant Mouse Afp protein, His-tagged Yeast His 19-605aa
Mouse Afp-2490M Recombinant Mouse Afp protein, His-tagged E.coli His 19-605aa
Rat Afp-126R Recombinant Rat Afp Protein, His/GST-tagged E.coli His/GST Glu409~Val611
Dog AFP-119D Recombinant Dog AFP Protein, His-tagged E.coli His Thr234~Leu380
Aspergillus giganteus afp-3937A Recombinant Aspergillus giganteus afp protein, His-B2M-tagged E.coli His-B2M 44-94aa
Cattle AFP-118C Recombinant Cattle AFP Protein, His-tagged E.coli His Asn14~Thr210
Pig AFP-123P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST Leu46~Thr210
Pig AFP-124P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST Ala263~Ser386
Pig AFP-125P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST Leu381~Glu567
Pig aFP-3365P Recombinant Pig aFP, His-tagged, GST-tagged E.coli His/GST 610
CDA001 Human Alpha Fetoprotein Antigen Grade Human Fetal Cord Serum N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AFP Related Articles
  • AFP Related Research Area

AFP involved in several pathways and played different roles in them. We selected most pathways AFP participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayBMP8B;YWHAZ;GSK3B;ITGB2;WTIP;AJUBA;TEAD2;FGF1;SMAD3

AFP has several biochemical functions, for example, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFP itself. We selected most functions AFP had, and list some proteins which have the same functions with AFP. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingING5A;ZBTB2B;LNX2A;ADCY1;ESR2B;TRAF4B;SMG6;CNOT8;ZHX2

AFP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFP here. Most of them are supplied by our site. Hope this information will be useful for your research of AFP.

Li, L; Xia, LR; et al. New method for fabricating an alpha-fetoprotein affinity monolithic polymer array. JOURNAL OF APPLIED POLYMER SCIENCE 132:-(2015).
Liu, YJ; Li, JS; et al. Theranostic Polymeric Micelles for the Diagnosis and Treatment of Hepatocellular Carcinoma. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11:613-622(2015).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can AFP protein be utilized as a diagnostic or prognostic marker for certain diseases or conditions, and what experimental studies can be conducted to validate its clinical utility? 09/09/2022

The clinical utility of AFP protein as a diagnostic or prognostic marker can be validated through clinical studies using patient samples, correlation analyses with disease outcomes, or comparison with existing diagnostic methods.

What are the downstream signaling pathways or cellular responses triggered by AFP protein binding or activation, and how can they be studied using molecular and cellular techniques? 08/02/2022

Downstream signaling pathways or cellular responses triggered by AFP protein binding or activation can be studied using techniques such as Western blotting, gene expression analysis, or functional assays specific to the signaling pathways of interest.

Can AFP protein be targeted or manipulated to develop therapeutic interventions or treatment strategies, and what experimental approaches can be used to evaluate their efficacy and safety? 12/29/2021

Therapeutic interventions or treatment strategies targeting AFP protein can be evaluated for efficacy and safety using in vitro or in vivo models, disease-specific assays, or clinical trials to assess their impact on disease progression, patient outcomes, or potential side effects.

What are the cellular and molecular mechanisms underlying the production and secretion of AFP protein, and how can they be experimentally elucidated? 03/28/2021

The cellular and molecular mechanisms underlying the production and secretion of AFP protein can be elucidated through techniques such as gene expression analysis, protein trafficking studies, or immunofluorescence microscopy.

Are there any genetic variations or mutations in the AFP gene that impact its expression or function, and what are the implications for disease susceptibility or clinical outcomes? 07/22/2018

Genetic variations or mutations in the AFP gene that impact its expression or function can be investigated through genetic association studies, functional characterization of mutant variants, or population-based analyses.

What are the regulatory factors or signaling pathways that control the expression and transcriptional regulation of AFP gene, and how can their involvement be studied? 12/19/2017

The regulatory factors or signaling pathways that control the expression and transcriptional regulation of the AFP gene can be studied using techniques such as promoter analysis, transcription factor binding assays, or gene knockout/knockdown approaches.

What are the functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression, and how can its biological functions be investigated experimentally? 04/30/2017

The functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression can be investigated through genetic or pharmacological perturbations, in vitro or in vivo model systems, or functional assays specific to the biological processes of interest.

Are there any specific biomarkers or imaging techniques that can be used to detect AFP protein in biological samples, and how can their sensitivity and specificity be assessed experimentally? 09/21/2016

Specific biomarkers or imaging techniques for detecting AFP protein in biological samples can be developed and their sensitivity and specificity can be assessed using techniques such as ELISA, immunohistochemistry, or imaging modalities like MRI or PET.

How does AFP protein interact with its binding partners or ligands, and what experimental approaches can be used to study these interactions? 10/05/2015

The interactions of AFP protein with its binding partners or ligands can be studied using techniques such as co-immunoprecipitation, surface plasmon resonance, or receptor-binding assays.

How does AFP protein contribute to immunomodulation or immune evasion, and what experimental strategies can be employed to investigate its immune-related functions? 05/24/2015

The immune-related functions of AFP protein, such as immunomodulation or immune evasion, can be investigated using techniques like immune cell assays, cytokine profiling, or immune response assays.

Customer Reviews (3)

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Reviews
11/14/2022

    Investigating protein-protein interactions in cellular stress responses for cell survival.

    02/15/2020

      Dissecting protein-protein interactions in viral replication for antiviral strategies.

      03/09/2017

        Mapping protein-protein interactions in protein degradation pathways for proteostasis.

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