Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

AMPH

  • Official Full Name

    amphiphysin

  • Overview

    This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.
  • Synonyms

    AMPH; amphiphysin; amphiphysin (Stiff Man syndrome with breast cancer 128kDa autoantigen) , amphiphysin (Stiff Mann syndrome with breast cancer 128kD autoantigen); amphiphysin I; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); AMP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMPH-312H Recombinant Human AMPH protein, GST-tagged Wheat Germ GST
Human AMPH-8875HCL Recombinant Human AMPH 293 Cell Lysate HEK293 N/A
Human AMPH-687HF Recombinant Full Length Human AMPH Protein, GST-tagged In Vitro Cell Free System GST 695 amino acids
Human AMPH-402H Recombinant Human AMPH Protein, His-tagged E.coli His Val24~Lys241
Human AMPH-0307H Recombinant Human AMPH Protein (Val24-Lys241), His-tagged E.coli His Val24-Lys241
Human AMPH-338H Recombinant Human AMPH Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse AMPH-1609M Recombinant Mouse AMPH Protein Mammalian Cell His
Mouse Amph-1616M Recombinant Mouse Amph Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AMPH-512M-B Recombinant Mouse AMPH Protein Pre-coupled Magnetic Beads HEK293
Mouse AMPH-512M Recombinant Mouse AMPH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Amph-403M Recombinant Mouse Amph Protein, His-tagged E.coli His Val24~Asp240
Rat Amph-3432R Recombinant Rat Amph, His-tagged E.Coli or Yeast His 683
Rat AMPH-660R Recombinant Rat AMPH Protein Mammalian Cell His
Rat AMPH-316R-B Recombinant Rat AMPH Protein Pre-coupled Magnetic Beads HEK293
Rat AMPH-316R Recombinant Rat AMPH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Amph-404R Recombinant Rat Amph Protein, His-tagged E.coli His Val24~Asp240
Zebrafish AMPH-11085Z Recombinant Zebrafish AMPH Mammalian Cell His
Chicken AMPH-1216C Recombinant Chicken AMPH Mammalian Cell His
Chicken AMPH-3431C Recombinant Chicken AMPH, His-tagged E.Coli or Yeast His 682
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMPH Related Research Area

AMPH involved in several pathways and played different roles in them. We selected most pathways AMPH participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMPH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisHRASB;WASLB;VPS25;CAV1;WIPF2B;GRK7A;ADRB3;RAB8A;USP8
Fc gamma R-mediated phagocytosisARPC1A;PPAP2B;BIN1;FCGR2A;WASF3;RAC1;SPHK1;ASAP3;RPS6KB2

AMPH has several biochemical functions, for example, phospholipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMPH itself. We selected most functions AMPH had, and list some proteins which have the same functions with AMPH. You can find most of the proteins on our site.

Function Related Protein
phospholipid bindingSMURF1;WDFY4;ABCA1;PACSIN1A;BAD;ARHGAP26;APOEA;SYT14;GRK5
protein bindingNAA50;BNIP3;GUCY1B3;FBLN1;EIF4A3;NAALADL2;CHDH;SCAMP2;SEMA4D

AMPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMPH here. Most of them are supplied by our site. Hope this information will be useful for your research of AMPH.

DNM1; DNM2; Ap2a2; Necap1; SYNJ1

  • Q&As
  • Reviews

Q&As (22)

Ask a question
Can AMPH protein affect other aspects of neuronal function? 11/30/2022

Yes, in addition to its role in synaptic vesicle endocytosis, AMPH protein can impact other aspects of neuronal function. For example, it has been suggested to play a role in regulating synaptic plasticity, which is essential for learning and memory. AMPH protein may also contribute to axonal growth and guidance during development, as well as neuronal migration in the developing brain.

What are the consequences of dysregulation of AMPH protein expression or function? 09/01/2022

Dysregulation of AMPH protein expression or function can have various consequences for neuronal function and synaptic vesicle recycling. Reduced or impaired AMPH protein function has been associated with decreased synaptic vesicle endocytosis, which can lead to reduced neurotransmitter release and impaired synaptic transmission. It may also impact synaptic plasticity, vesicle pool replenishment, and overall synaptic activity. Dysregulation of AMPH protein has been implicated in neurological and psychiatric disorders, highlighting its importance in neuronal physiology.

Can AMPH protein be targeted for therapeutic purposes in psychiatric disorders? 06/30/2022

As our understanding of the role of AMPH protein in psychiatric disorders grows, it may become a potential target for therapeutic interventions. However, developing specific drugs that modulate AMPH activity or its associated pathways is challenging and would require further research and development.

Are there any drugs or therapies targeting AMPH protein? 06/16/2022

Currently, there are no specific drugs or therapies targeting AMPH protein. However, research into understanding its role in neurological disorders may lead to potential therapeutic approaches in the future.

Can AMPH protein be found in other tissues apart from the brain? 03/24/2022

While AMPH protein is predominantly found in the brain and the nervous system, it has also been identified in other tissues to a lesser extent. These include tissues like the adrenal gland, kidney, and pancreas.

How is the expression of AMPH protein regulated in neurons? 12/10/2021

The expression of AMPH protein in neurons is regulated by various mechanisms. Transcription factors, such as myocyte enhancer factor 2 (MEF2) and neurogenic differentiation factor 1 (NeuroD1), can bind to the regulatory regions of the AMPH gene and control its expression. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can influence AMPH gene expression. Furthermore, signaling pathways, like the cAMP-PKA pathway, can modulate AMPH protein expression through phosphorylation events.

Is there any association between AMPH protein and neurodegenerative diseases? 10/05/2021

AMPH protein has not been directly linked to neurodegenerative diseases. However, some studies have suggested its involvement in Parkinson's disease, a neurodegenerative disorder. Further research is needed to fully understand the relationship between AMPH protein and neurodegenerative diseases.

Is there any evidence to suggest a role for AMPH protein in neurodegenerative diseases? 08/08/2021

While research on the involvement of AMPH protein in neurodegenerative diseases is limited, there is emerging evidence to suggest its potential involvement. Studies have shown altered expression of AMPH protein in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

What happens when AMPH protein is mutated or dysregulated? 05/25/2021

Mutations or dysregulation of AMPH protein can disrupt synaptic vesicle endocytosis and neurotransmitter release, leading to impaired synaptic transmission. This can contribute to neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease.

Are there any known interactions between AMPH protein and other proteins or signaling pathways? 03/05/2021

Yes, AMPH protein interacts with several other proteins and signaling pathways. One important interaction is with dynamin, a protein involved in vesicle scission during endocytosis. AMPH also interacts with clathrin, which is involved in the formation of clathrin-coated vesicles. Additionally, AMPH can interact with other synaptic proteins, such as synapsin and synaptophysin, which regulate synaptic vesicle trafficking.

How is AMPH protein involved in synaptic vesicle recycling? 02/19/2021

AMPH protein plays a crucial role in synaptic vesicle endocytosis, a process essential for rapid recycling of vesicles after neurotransmitter release. Upon stimulation, AMPH protein is recruited to clathrin-coated pits, where it promotes vesicle membrane invagination and subsequent fission from the plasma membrane. This activity depends on the N-terminal BAR domain of AMPH, which binds to and induces membrane curvature.

Where is AMPH protein found? 09/21/2020

AMPH protein is found mainly in the brain and the nervous system, particularly in synapses.

Does AMPH protein have any functional link to psychiatric disorders? 07/10/2020

There is evidence to suggest that AMPH protein may be implicated in the pathophysiology of psychiatric disorders. Genetic studies have identified variations in the AMPH gene associated with psychiatric conditions such as schizophrenia and bipolar disorder.

How is the expression of AMPH protein regulated? 02/08/2020

The expression of AMPH protein can be regulated at the transcriptional level through interactions with transcription factors or signaling pathways. Additionally, post-translational modifications, such as phosphorylation, can affect its activity and stability.

How is the activity of AMPH protein regulated during synaptic vesicle endocytosis? 12/29/2019

The activity of AMPH protein is tightly regulated during synaptic vesicle endocytosis. It can be controlled through phosphorylation by various kinases, such as cyclin-dependent kinase 5 (CDK5) or cAMP-dependent protein kinase (PKA). These phosphorylation events can modulate AMPH protein function and localization, impacting its role in vesicle endocytosis.

Are there any known cellular or animal models used to study AMPH protein? 10/16/2019

Yes, several cellular and animal models have been used to study AMPH protein function. These include cell culture models, such as neuronal cell lines or primary neuronal cultures, where the effects of manipulating AMPH expression or function can be assessed. Animal models, such as mice or flies, with genetic modifications in the AMPH gene or alterations in AMPH protein expression, have also been used to investigate its role in neuronal function and disease. These models provide valuable insights into the cellular and physiological consequences of AMPH protein dysfunction.

Are there any known drugs that can modulate AMPH protein function or expression? 08/03/2019

Currently, there are no drugs specifically designed to target AMPH protein function or expression. However, certain medications used in the treatment of neurological and psychiatric disorders indirectly affect AMPH-related pathways. For example, drugs that increase dopamine or norepinephrine levels, such as amphetamines or certain antidepressants, can affect AMPH protein function.

What are the current areas of research on AMPH protein? 01/19/2019

Current areas of research on AMPH protein include investigating its precise mechanisms in synaptic vesicle endocytosis, understanding its role in neurological disorders, and exploring potential therapeutic strategies targeting AMPH-related pathways.

How is AMPH protein involved in synaptic vesicle endocytosis? 10/12/2018

AMPH protein interacts with other proteins, such as dynamin and clathrin, to facilitate the formation of clathrin-coated vesicles. These vesicles engulf the neurotransmitter-filled synaptic vesicle membrane after neurotransmitter release, allowing for its retrieval and recycling.

Can AMPH protein be targeted for therapeutic interventions? 06/03/2017

Although there are currently no specific drugs targeting AMPH protein, understanding its role in neurological disorders may lead to potential therapeutic interventions in the future. Strategies could involve modulating the activity of proteins interacting with AMPH, or exploring AMPH-related pathways for drug development.

Are there any animal models used to study AMPH protein? 03/05/2017

Yes, various animal models have been developed to study the function and role of AMPH protein. This includes genetically modified mice with altered AMPH expression or mutations in the AMPH gene. These models allow researchers to investigate the impact of AMPH dysfunction on synaptic vesicle endocytosis and neurotransmission.

Can AMPH protein be a target for drug development in neurodegenerative diseases? 07/28/2016

The potential of targeting AMPH protein for therapeutic purposes in neurodegenerative diseases is not well-established. While its involvement in these conditions suggests a possible avenue for drug development, more research is needed to determine the extent of its contribution and to identify specific mechanisms that could be targeted. This would involve understanding the precise role of AMPH protein in neurodegeneration and developing strategies to modulate its activity or expression.

Customer Reviews (5)

Write a review
Reviews
10/17/2021

    Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the AMPH protein.

    05/30/2021

      Its impeccable purity and integrity make it a valuable asset in my research endeavors.

      02/21/2019

        Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

        08/15/2018

          The AMPH protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.

          02/02/2016

            This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

            Ask a Question for All AMPH Products

            Required fields are marked with *

            My Review for All AMPH Products

            Required fields are marked with *

            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends