BACE1
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Official Full Name
beta-site APP-cleaving enzyme 1
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Overview
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] -
Synonyms
BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Wheat Germ
- C
- hFc
- His
- Fc
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- human|IgG1|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BACE1 Related Articles
- BACE1 Related Research Area
BACE1 involved in several pathways and played different roles in them. We selected most pathways BACE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alzheimers disease | IDE;NDUFA9;PLCB4;UQCR10;COX5A;UQCRC1;AKR1C1;SDHA;APBB1 |
BACE1 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding, beta-aspartyl-peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BACE1 itself. We selected most functions BACE1 had, and list some proteins which have the same functions with BACE1. You can find most of the proteins on our site.
Function | Related Protein |
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aspartic-type endopeptidase activity | PGA;DDI2;ATP6AP2;PSEN1;PGA4;ANK2B;Casp3;CNTNAP5A;SPPL3 |
beta-amyloid binding | SORL1;IDE;CD74;CST3;CLSTN1;NGFR;LDLRAP1;APOE;APBA3 |
beta-aspartyl-peptidase activity | |
enzyme binding | PUS7;ITGB3;EGLN1;TH;PCBP2;CASP2;ESR2;PTEN;MAPT |
peptidase activity | CTSM;GZMF;AZU1;SPCS3;ELA2;MCPT1;DESI2;PRSS30;PCSK5 |
protein binding | SUV39H2;BTK;ZNF230;DYRK2;MDFI;KIF2C;CXCL10;DIS3L2;NOL9 |
BACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BACE1.
Clec4g; FLOT2; APP; Flot1; FLOT1; MMP2; CSNK1D; App
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.
BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.
BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.
Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.
Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.
Customer Reviews (3)
Write a reviewSuch support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.
A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.
Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.
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