BAD
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Official Full Name
BCL2-associated agonist of cell death
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Overview
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008] -
Synonyms
BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- BAD Related Articles
- BAD Related Gene Family
- BAD Related Signal Pathway
BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway, Ras signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | MAPK10;MAPK8A;RAF1B;CAMK2B1;EREG;MAP2K1;ABL2;KRAS;HRASA |
| Ras signaling pathway | PLA2G5;GNG5;PIK3CB;Fgf15;GNGT1;VEGFA;FGF6;IGF1;LOC608458 |
| cGMP-PKG signaling pathway | AGTR1B;Adcy4;PLCB3;NFATC4;ATP1B1;PLCB4;ITPR3;CALM3;NOS3 |
| cAMP signaling pathway | GHRL;SOX9;BDNF;RRAS2;SLC9A1;GRIN1;PDE3A;GNAI1;GLI3 |
| PIK-Akt signaling pathway | IGF1R;CCND3;ITGA10;GNB4;NRAS;PKN1;PPP2R2B;TLR4;FGF5 |
| Apoptosis | IL1B2;CASP6;BIRC8;IRF1B;IRF2A;CAPN1;CAPN1A;PPP3CCB;PPP3R2 |
| VEGF signaling pathway | PXN;MAPK12B;HRASA;PLA2G4AA;PLA2G4F;PIK3CB;PPP3R1B;NOS3;PPP3R1 |
| Focal adhesion | COL1A1B;GRB2B;COL5A2;PXN;PAK2B;LAMA2;RAPGEF1B;PARVAA;CAPN2 |
| Neurotrophin signaling pathway | BCL2;SHC3;PDPK1;ZFP110;NTRK2;MAPK1;MATK;RPS6KA3;SHC2 |
| Insulin signaling pathway | MAPK8B;PRKACBA;PDPK1B;PRKAR1A;PRKACAB;CBLB;PPP1R3D;CALM3B;TRIP10A |
| Thyroid hormone signaling pathway | HDAC1;PRKCA;ATP1A1;ATP1B4;NOTCH4;ACTB;MED4;HDAC2;ATP2A2 |
| Alzheimers disease | SDHA;CALML5;APH1B;COX6A1;APBB1;PLCB4;EIF2AK3;COX5B;NDUFS8 |
| Amyotrophic lateral sclerosis (ALS) | CAT;APAF1;TNFRSF1B;MAPK13;PPP3R1;GRIN2B;NEFH;TNFRSF1A;Casp3 |
| Toxoplasmosis | LY96;CASP8;HLA-DRB3;CD40;NFKBIB;IL10RA;HSPA1B;HSPA2;HLA-DRB5 |
| Tuberculosis | EP300;ATP6V0B;MAPK12;CD74;BAD;NFYB;ITGB2L;CLEC4M;PPP3CB |
| Hepatitis C | IFNA5;IFIT1;AKT1;IFNA6;STAT2;PIAS1;MAPK8;IFNA13;RXRA |
| Hepatitis B | HBXIP;IFNA2;TRP53;Ifna11;PIK3R3;IRF7;CCNA1;DDB2;STAT2 |
| Pathways in cancer | GNG5;PRKACB;BIRC2;SPI1;WNT3A;PPARD;HSP90B1;GNA12;FADD |
| Viral carcinogenesis | IL6ST;STAT5B;BAD;PIK3CA;MAPKAPK2;ACTN1;DLG1;DNAJA3;PSMC1 |
| Colorectal cancer | MAPK1;MAPK10;SMAD4;KRAS;BAX;PIK3R5;BAD;AXIN2;RHOA |
| Pancreatic cancer | STAT1;PIK3R5;PIK3R2;PIK3R3;RAC2;TP53;BRCA2;SMAD3;CCND1 |
| Endometrial cancer | TP53;ILK;ERBB2;CTNNA3;CASP9;RAF1;GRB2;ELK1;BRAF |
| Prostate cancer | MAP4K1;PDGFA;CREB3L1;CREB3L2;HSP90AA1;CPN1;ARID1A;HSP90B1;GSTP1 |
| Melanoma | FGF17;HRAS;FGF22;FGF3;PIK3R1;PDGFRB;RAF1;FGF11;TRP53 |
| Chronic myeloid leukemia | HDAC1;PIK3R5;STAT5A;ABL1;SMAD3;TGFB3;MAPK3;CBLB;PIK3CG |
| Acute myeloid leukemia | MAP2K2;MAPK1;SPI1;JUP;CCNA1;FLT3;STAT5B;STAT5A;NFKB1 |
| Non-small cell lung cancer | CCND1;RARB;STK4;MAP2K2;PDPK1;FOXO3;PIK3R1;RXRA;TGFA |
BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activator activity involved in apoptotic process | PYCARD;CTSH;APAF1;GNB2L1;CARD8;MAPK9;CASP1;NLRP1;BAD |
| lipid binding | OSBPL9;APOA4A;STARD13;BPIFB6;ANXA6;PTGS1;SH3GL2;FABP11A;SNX10B |
| phospholipid binding | ABCA1;NOXO1;ANXA5;PSD2;PLA2G15;PACSIN1A;SMURF1;OSBPL1A;APOEA |
| protein binding | XPO7;MOAP1;MAP1LC3C;FYB;NAE1;GPR85;POLR2C;PELI1;STX11 |
| protein heterodimerization activity | RAF1;IKBKB;PDX1;TAF11;MCL1B;TLR2;HIST1H2AB;BCL2L1;HIST3H2A |
| protein kinase B binding | CCDC88A;ANKRD2;BCL10;PDE3B;TRAF6;CDC37;PINK1;RARA;APPL1 |
| protein kinase binding | DOK7;HSP90AB1;PPME1;PRC1;KCNH1;ZC3HC1;TSKS;TRIM6;TEX14 |
| protein phosphatase 2B binding | BAD;SOD1;PPP3CB;MYOZ2;SLC9A1;ATP2B4;AKAP5;AKAP1 |
BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.
BCL2L1; BCL2; BCL2L1
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