C2
-
Official Full Name
complement component 2
-
Overview
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009] -
Synonyms
C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II)
- C
- His
- Fc
- hFc
- His (Fc)
- Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | C2-98H | Active Native Human C2 Protein | Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II) | N/A | ||
Human | C2-6878H | Active Recombinant Human C2 protein(Met1-Leu752), His-tagged | HEK293 | C-His | Met1-Leu752 | |
Human | C2-26739TH | Recombinant Human C2 | E.coli | N/A | ||
Human | C2-599H | Recombinant Human Complement Component 2, Fc Chimera | HEK293 | Fc | ||
Human | C2-7265H | Recombinant Human C2 protein, hFc-tagged | HEK293 | hFc | Met1-Leu752 | |
Human | C2-7846H | Recombinant Human C2 protein, His & T7-tagged | E.coli | His/T7 | Ile245~His451 (Accession # P06681) | |
Human | C2-598H | Recombinant Human Complement Component 2, His-tagged | HEK293 | His | ||
Human | C2-3068HCL | Recombinant Human C2 cell lysate | Human Cell | N/A | ||
Human | C2-1032H | Active Recombinant Human C2 protein, His-tagged | HEK293 | His | Ala21-Leu752 | |
Human | C2-0620H | Recombinant Human C2 Protein (Ile245-His451), N-His-tagged | E.coli | N-His | Ile245-His451 | |
Mouse | C2-1012M | Active Recombinant Mouse C2 Protein, His-tagged | Mammalian cells | His | Met1-Leu760 | |
Mouse | C2-480M | Recombinant Mouse C2, His-tagged | Human Cell | His | Met1-Leu760 | |
Mouse | C2-001MCL | Recombinant Mouse C2 cell lysate | Human Cell | N/A | ||
Mouse | C2-1143M-B | Recombinant Mouse C2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | C2-1143M | Recombinant Mouse C2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | C2-7847R | Recombinant Rat C2 protein, His & T7-tagged | E.coli | His/T7 | Asn473~Arg723 (Accession# Q6MG73) | |
Cynomolgus | C2-1878C | Active Recombinant Cynomolgus C2 protein, His-tagged | HEK293 | His | Ala 21 - Leu 752 |
- Involved Pathway
- Protein Function
- Interacting Protein
- C2 Related Articles
- C2 Related Research Area
C2 involved in several pathways and played different roles in them. We selected most pathways C2 participated on our site, such as Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Complement and coagulation cascades | SERPINE1;C4BPB;BDKRB2;C5AR1;F7;CD59;PROC;PROS1;FGG |
Pertussis | C4BPA;ITGB2L;MAPK13;ITGA5;MAPK9;GNAI2;ITGAM;CXCL6;MAPK11 |
Staphylococcus aureus infection | C1QA;FPR3;C1R;Itgam&Itgb2;HLA-DRB3;CFB;HLA-DMA;HLA-DPB1;FCGR1 |
Systemic lupus erythematosus | HIST1H2BN;HIST1H3F;HIST1H3I;ACTN2;C4A;HIST1H3A;CD40LG;HIST2H3C1;GM14476 |
C2 has several biochemical functions, for example, metal ion binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C2 itself. We selected most functions C2 had, and list some proteins which have the same functions with C2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
metal ion binding | ZFAND5B;SUMF1;ZNF524;MMP23BB;CA14;TRIM43A;ZNF518A;ZFP787;TRMT1L |
serine-type endopeptidase activity | HTRA1;PCSK9;LPA;MST1;PROC;KLK10;GZMF;FURIN;HPR |
C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of C2.
q81l39_bacan
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, drugs targeting C2 or the complement system are being explored as potential treatments for autoimmune diseases to regulate the immune response.
Yes, the absence or dysfunction of C2 protein can be indicative of immune system disorders, and its levels can be assessed for diagnostic purposes.
Understanding C2's role in immune activation may contribute to vaccine design, potentially enhancing the effectiveness of vaccines by targeting the complement system.
Abnormal activation of the complement system, including C2, is associated with some autoimmune diseases where the immune system mistakenly attacks the body's own cells.
Yes, genetic variations can affect C2 protein expression and function, leading to variations in immune response among individuals.
Customer Reviews (3)
Write a reviewThe C2 protein comes highly recommended for its excellent performance in various research applications.
It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.
Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
Ask a Question for All C2 Products
Required fields are marked with *
My Review for All C2 Products
Required fields are marked with *