c2
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  • Official Full Name
  • complement component 2
  • Background
  • Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
  • Synonyms
  • C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2;
Cat.#:C2-26739THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C2
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Cat.#:C2-6878HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human C2, His tagged
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Cat.#:C2-7265HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human C2, Fc tagged
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Cat.#:C2-7846HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C2 protein, His & T7-tagged
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Cat.#:C2-1012MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse C2 Protein, His-tagged
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Cat.#:C2-480MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse C2, His-tagged
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Cat.#:C2-7847RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat C2 protein, His & T7-tagged
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Cat.#:C2-598HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Complement Component 2, His-tagged
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Cat.#:C2-599HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Complement Component 2, Fc Chimera
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Cat.#:C2-98HTag:
Source (Host):Species:Human
Product nameNative Human C2 Protein
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Cat.#:C2-3068HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human C2 cell lysate
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Cat.#:C2-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse C2 cell lysate
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C2 Related Articles

Kahle, J; Orlowski, A; et al. Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. THROMBOSIS AND HAEMOSTASIS 113:396-405(2015).
Shetty, KA; Kosloski, MP; et al. Soy Phosphatidylinositol Containing Nanoparticle Prolongs Hemostatic Activity of B-Domain Deleted Factor VIII in Hemophilia A Mice. JOURNAL OF PHARMACEUTICAL SCIENCES 104:388-395(2015).