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CASP10

  • Official Full Name

    caspase 10, apoptosis-related cysteine peptidase

  • Overview

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
  • Synonyms

    CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP10-247H Active Recombinant Human CASP10, His-tagged E.coli His
Human CASP10-597H Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase E.coli N/A
Human CASP10-26813TH Recombinant Human CASP10 E.coli N/A
Human CASP10-26815TH Recombinant Human CASP10 E.coli N/A
Human CASP10-299H Recombinant Human CASP10 Protein, His-tagged E.coli His
Human CASP10-598H Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase E.coli N/A
Human CASP10-300H Recombinant Human CASP10 Protein, His-tagged E.coli His
Human CASP10-0414H Recombinant Human CASP10 Protein, GST-Tagged Wheat Germ GST
Human CASP10-557H Recombinant Human CASP10 Mammalian Cell His
Human CASP10-2924HF Recombinant Full Length Human CASP10 Protein, GST-tagged In Vitro Cell Free System GST 479 amino acids
Human CASP10-2591H-B Recombinant Human CASP10 Protein Pre-coupled Magnetic Beads HEK293
Human CASP10-1125H Recombinant Human CASP10 Protein (Phe223-Ile459), N-His tagged E.coli N-His Phe223-Ile459
Human CASP10-2591H Recombinant Human CASP10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CASP10-1265H Recombinant Human CASP10 Protein (Val220-Thr480), C-His tagged E.coli C-His Val220-Thr480
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CASP10 involved in several pathways and played different roles in them. We selected most pathways CASP10 participated on our site, such as Apoptosis, RIG-I-like receptor signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisIL3;DIABLO;CTNNB2;CASP10;CASP2;OCLN;NFKBIAA;JUN;STK24
RIG-I-like receptor signaling pathwayRIPK1;PL10;IFNB1;IFNA13;IFNA3;TMEM173;CXCL10;MAPK12A;IFNA7
TNF signaling pathwayCASP10;LTA;PIK3R1;CXCL10;PIK3R5;MAPK10;CREB3L3;PGAM5;BAG4
TuberculosisIL23;TGFB3;HLA-DRB1;NFYC;MAPK12;HLA-DRA;MRC2;Casp3;FCGR2A
Hepatitis BCREB3L2;IKBKB;IFNA13;HBXIP;TP53;MMP9;NFATC1;IFNA5;BIRC5

CASP10 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP10 itself. We selected most functions CASP10 had, and list some proteins which have the same functions with CASP10. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityUSP17L5;USP19;CTSH;USP16;ATG4C;USP12;CASP3B;USP3;USP14
cysteine-type endopeptidase activity involved in apoptotic signaling pathwayCASP10;CASP9;CASP2;CFLARA;CASP8;CFLAR;CASP8L1;CASP14
death effector domain bindingCASP8;CFLAR;CFLARA;FADD;CASP10;CASP8L1;NOL3
protein bindingUSP25;NEK9;PLCB4;LGI4;MAPT;TMPO;CDK15;GPM6A;PDE6G
ubiquitin protein ligase bindingMAGEA2;ERBB2;UBE2G1B;SCAMP3;RNF31;TRIB3;CUL3B;HSPA1L;SMAD7

CASP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP10.

FADD; CASP8; CFLAR; RIOK3; XIAP

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