CASP8
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Official Full Name
caspase 8, apoptosis-related cysteine peptidase
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Overview
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] -
Synonyms
CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Tag Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CASP8-26H | Active Recombinant Human CASP8, His-tagged | E.coli | His | ||
Human | CASP8-404H | Recombinant Human Caspase 8, Apoptosis-Related Cysteine Peptidase | E.coli | N/A | ||
Human | CASP8-7828H | Recombinant Human CASP8 protein, His & T7-tagged | E.coli | His/T7 | Leu385~Asp479 (Accession# Q14790) | |
Human | CASP8-26606TH | Active Recombinant Human CASP8 Protein | E.coli | N/A | ||
Human | CASP8-7829H | Recombinant Human CASP8 protein, His-tagged | E.coli | His | Leu7~Asp201 | |
Human | CASP8-147H | Recombinant Human CASP8 Protein, His-tagged | E.coli | His | ||
Human | CASP8-7829HCL | Recombinant Human CASP8 293 Cell Lysate | HEK293 | N/A | ||
Human | CASP8-7830HCL | Recombinant Human CASP8 293 Cell Lysate | HEK293 | N/A | ||
Human | CASP8-7831HCL | Recombinant Human CASP8 293 Cell Lysate | HEK293 | N/A | ||
Human | CASP8-0834H | Recombinant Human CASP8 Protein (Ser217-Asp479), N-His tagged | E.coli | N-His | Ser217-Asp479 | |
Human | CASP8-0863H | Recombinant Human CASP8 Protein | E.coli | Tag Free | ||
Human | CASP8-4937H | Recombinant Human CASP8 Protein(217–374aa), His-tagged | E. coli | N-His | 217–374aa | |
Mouse | Casp8-1645M | Recombinant Mouse Caspase 8 | E.coli | N/A | ||
Mouse | CASP8-2756M | Recombinant Mouse CASP8 Protein | Mammalian Cell | His | ||
Mouse | Casp8-7830M | Recombinant Mouse Casp8 protein, His & T7-tagged | E.coli | His/T7 | Ser219~Gly376 (Accession # O89110) | |
Mouse | Casp8-7831M | Recombinant Mouse Casp8 protein, His & T7-tagged | E.coli | His/T7 | Met1~Asp218 (Accession # O89110) | |
Mouse | CASP8-1247M | Recombinant Mouse CASP8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | CASP8-1247M-B | Recombinant Mouse CASP8 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Casp8-7832R | Recombinant Rat Casp8 protein, His & T7-tagged | E.coli | His/T7 | Tyr8~Val197 (Accession# Q9JHX4) | |
Rat | CASP8-1146R | Recombinant Rat CASP8 Protein | Mammalian Cell | His | ||
Rat | CASP8-804R | Recombinant Rat CASP8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CASP8-804R-B | Recombinant Rat CASP8 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cattle | CASP8-7827C | Recombinant Cattle CASP8 protein, His-tagged | E.coli | His | Leu25~Ile175 (Accession # Q2LGB8) | |
Zebrafish | CASP8-9059Z | Recombinant Zebrafish CASP8 | Mammalian Cell | His | ||
Chicken | CASP8-6161C | Recombinant Chicken CASP8 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CASP8 Related Articles
- CASP8 Related Research Area
CASP8 involved in several pathways and played different roles in them. We selected most pathways CASP8 participated on our site, such as p signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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p signaling pathway | GADD45AA;PERP;THBS1;PPM1DA;CASP9;FAS;BAI1;SESN2;BBC3 |
Apoptosis | DBNLB;Gzmg;Casp3;IRF2A;DCC;DYNLL2;CAPN2B;PRKACAB;ADD1 |
Toll-like receptor signaling pathway | FADD;IFNA6;IFNPHI1;PIK3CG;AKT2L;LBP;IFNA1;CXCL8B.3;MAPK8B |
NOD-like receptor signaling pathway | IL8L1;MAPK12A;NLRP3;NAIP1;IL6;NFKBIAA;CXCL2;CASP5;IKBKG |
RIG-I-like receptor signaling pathway | TRAF2;NFKBIAB;CXCL8B.3;TBK1;MAPK12A;DDX58;IFNE;AZI2;ATG12 |
TNF signaling pathway | Casp3;MAPK3;TRAF1;CCL5;IL6;MAP3K14;MMP3;FAS;MAP2K3 |
Non-alcoholic fatty liver disease (NAFLD) | MAPK10;PIK3R5;NDUFC2;PIK3CB;UQCRFS1;MAPK9;NDUFB8;NDUFA4;COX7A2L |
Alzheimers disease | NDUFB11;COX6B1;NDUFC2-KCTD14;ATP5F1;CAPN2;ATP5J;ATP5G3;UQCRFS1;NDUFA5 |
Huntingtons disease | PLCB4;NDUFV1;SIN3A;COX6B1;VDAC2;NDUFA12;POLR2C;ATP5J;DNAH5 |
Legionellosis | SAR1A;CXCL1;VCP;C3;TLR5;BNIP3;CR1;CASP1;NAIP6 |
Chagas disease (American trypanosomiasis) | AKT1;Il2;FADD;CCL5;IL12A;IL12B;TGFBR2;CASP8;IL1B |
Toxoplasmosis | HLA-DPA1;HSPA1A;HSPA6;BCL2;MAPK10;NFKBIB;BCL2L1;IKBKB;IRGM1 |
Tuberculosis | CAMK2D;PLK3;Il23a; Il12b;BCL2;TRADD;ITGAX;H2-AA;TLR1;TGFB3 |
Hepatitis B | PIK3R1;IFNA12;CCNE1;BCL2;PTEN;CYCS;IFNA2;MAPK8;EGR3 |
Herpes simplex infection | PER3;BLB2;CD74A;SRSF9;HLA-DQB1;EEF1D;IFN-a;TLR2-2;TRAF3 |
Pathways in cancer | MMP2;TRAF1;AHA-1;MAX;BCL2L1;FGF6;GNG12;GNGT2;ARAF |
Viral carcinogenesis | HNRNPK;HLA-C;HPN;CREB3L2;GTF2A2;TBPL1;HDAC7A;BAD;CASP8 |
Viral myocarditis | Casp3;CCND1;H2-AA;ICAM1;HLA-DRA;HLA-G;HLA-DQB1;HLA-DRB4;CD80 |
CASP8 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP8 itself. We selected most functions CASP8 had, and list some proteins which have the same functions with CASP8. You can find most of the proteins on our site.
Function | Related Protein |
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cysteine-type endopeptidase activity | USP30;USP50;ATG4D;CASP8;CASP6L2;CTSB;CTSM;CASP3A;USP44 |
cysteine-type endopeptidase activity involved in apoptotic process | CLC;Casp3;CASP8 |
cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CASP2;CASP8;CFLAR;CASP8L1;CASP14;CASP10;CFLARA;CASP9 |
cysteine-type peptidase activity | UFSP2;CASPC;USP27X;CASPBL;CTSSB.2;CTSJ;ATG4B;OTUD6B;CTSK |
death effector domain binding | CASP8L1;CASP10;NOL3;CASP8;CFLARA;CFLAR;FADD |
death receptor binding | FASLG;BID;PIDD1;NOL3;CFLAR;TNFSF15;RIPK1;CASP8;Casp3 |
peptidase activity | CTSSA;DCD;lon;AGBL1;NAALADL1;CPD;CTS7;CAPN1A;CTSLL |
protein binding | ITCH;AIMP2;ARL3;CTR9;DCP1B;SAFB2;SLC35A2;PRPS1;RAB11FIP5 |
protein complex binding | YWHAB;PTCH1;DRD1;RRAS;LCK;ATP6V0D1;TRADD;CDK5RAP1;PRMT5 |
protein heterodimerization activity | MAFA;SOX32;HIST3H2BB;UGT1A4;RRAGA;TGFB2;HIST1H4G;MTTP;VAPA |
scaffold protein binding | KRT15;NLRP1;MAP2K2;GRIN2A;PDE4D;DSP;KCNQ1;TREM2;CHRNA7 |
tumor necrosis factor receptor binding | EDA;TNFSF10L3;TNFSF11;TNFSF12;TRAF4;TNFSF13B;TNFSF4;TRIM37;TRAP1 |
ubiquitin protein ligase binding | FAF2;PER1;RBX1;CUL4A;UBE2L3;PA2G4;MAGEA2B;DNM1L;HSPA1A |
CASP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP8.
FADD
- Q&As
- Reviews
Q&As (6)
Ask a questionStudying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.
The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.
Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.
Customer Reviews (3)
Write a reviewCASP8 is highly stable.
The reduction of the synthesis cost of this protein leads to the increase of the application.
CASP8 has a high specificity.
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