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CREB1

  • Official Full Name

    cAMP responsive element binding protein 1

  • Overview

    CREB (cAMP response element-binding) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
  • Synonyms

    CREB1; cAMP responsive element binding protein 1provided; CREB; MGC9284; cyclic AMP-responsive element-binding protein 1; CREB-1; OTTHUMP00000163864; OTTHUMP00000163865; OTTHUMP00000206660; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CREB1-26H Recombinant Human CREB1 E.coli N/A
Human CREB1-182H Recombinant Human CREB1 Protein, His-tagged E.coli His
Human CREB1-162H Recombinant Human CREB1, GST-tagged E.coli GST
Human CREB1-6915H Recombinant Human CREB1, His & MBP tagged E.coli His/MBP
Human CREB1-1839H Recombinant Human CREB1 Protein, GST-tagged Wheat Germ GST
Human CREB1-7289HCL Recombinant Human CREB1 293 Cell Lysate HEK293 N/A
Human CREB1-2260HF Recombinant Full Length Human CREB1 Protein, GST-tagged In Vitro Cell Free System GST 341 amino acids
Human CREB1-2732H Recombinant Human CREB1 protein, His-tagged E.coli His 1-341aa
Human CREB1-183H Recombinant Human CREB1, His-tagged E. coli His Ile102~Asp341
Human CREB1-1107H Recombinant Human CREB1 Protein Mammalian cell His
Human CREB1-468HFL Recombinant Full Length Human CREB1 Protein, N-His-tagged E.coli His
Human CREB1-1804H Recombinant Human CREB1 Protein (Lys122-Asp327), N-His tagged E.coli N-His Lys122-Asp327
Human CREB1-1803H Recombinant Human CREB1 Protein (Lys136-Asp341), His tagged E.coli His Lys136-Asp341
Rat CREB1-1588R Recombinant Rat CREB1 Protein Mammalian Cell His
Rat Creb1-1443R Recombinant Rat cAMP Responsive Element Binding Protein 1, GST-tagged E.coli GST
Rat CREB1-1245R-B Recombinant Rat CREB1 Protein Pre-coupled Magnetic Beads HEK293
Rat CREB1-1245R Recombinant Rat CREB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CREB1-1019R Recombinant Rhesus monkey CREB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CREB1-844R Recombinant Rhesus Macaque CREB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CREB1-844R-B Recombinant Rhesus Macaque CREB1 Protein Pre-coupled Magnetic Beads HEK293
Chicken CREB1-6020C Recombinant Chicken CREB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CREB1 Related Articles
  • CREB1 Related Signal Pathway

CREB1 involved in several pathways and played different roles in them. We selected most pathways CREB1 participated on our site, such as AKT phosphorylates targets in the nucleus, AMPK signaling pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AKT phosphorylates targets in the nucleusCREB1;CREB1B;AKT3
AMPK signaling pathwayCRTC2;TSC2;PIK3CB;PPP2R2B;PDPK1;STK11;HNF4A;CAMKK1;CD36
ATF-2 transcription factor networkJUN;CREB1;GADD45A;JDP2;RUVBL2;POU2F1;CDK4;CBFB;HRK
ATM Signaling PathwayCREB1;GADD45A
Activated TLR4 signallingTANK;PELI3;TNIP2;TICAM1;DHX9;APPB;PELI1;AGER;UBE2V1
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsADCY8;NEFLB;AKAP9;CREB1B;DLG4;PDPK1A;ADCY3;ADCY1;CAMKK1B
Adaptive Immune SystemLCP2A;RNF220;UBR2;PIK3AP1;KLB;EGFR;ASB17;AKR1C1;ACTR1B
AdipogenesisKLF7A;BMP1;EGR2B;CEBPB;MEF2B;CDKN1A;GATA2;STIL;CELF1

CREB1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB1 itself. We selected most functions CREB1 had, and list some proteins which have the same functions with CREB1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II activating transcription factor bindingJUN;CREBBP;TBX20;TP53BP1;EOMES;SIN3A;MAD2L2;ATF2;T
RNA polymerase II core promoter proximal region sequence-specific DNA bindingELK1;CEBPA;IFI203;ZNF395;NR3C1;ZIC1;SREBF1;TCF12;PATZ1
RNA polymerase II distal enhancer sequence-specific DNA bindingBACH2;RXRB;ZBTB16;NFE2L1;GZF1;ESRRB;REL;SFPQ;BACH1
cAMP response element bindingCREB3;ATF6B;CREB1;CREB3L3A;ATF2;ATF6;JUN;CREB3L3;CREB3L1
enzyme bindingDDX5;PLSCR4;CABYR;POLB;ANK1;ERN1;PYCARD;HMGA1-RS1;BTG1
histone acetyltransferase bindingETS1;NR4A3;EID1;SIRT2;PCNA;TP53;PAX6;EPAS1;GLI3
protein bindingNR1D2;KPNA1;TMEM88;PRKCD;NAT8B;HPRT1;SYF2;APBB1;ATG13
transcription cofactor activityCALCOCO1;FAM48A;MED17;PIR;TMF1;ZNF763;AIRE;WDR75;SND1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingPURA;NKX2-5;NR5A1;MEF2C;PKNOX1;ATF2;TEAD2;POU3F1;MEIS1
transcription factor activity, sequence-specific DNA bindingZSCAN4F;ZNF274;ZNF227;DMRT2;ZNF167;BACH1A;FOXK2;HOXD4;FOXA3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingZIC3;TFAP2E;CAMTA2;FUBP3;PAX8;PITX3;POU2F2;NR5A2;MEF2A
transcriptional activator activity, RNA polymerase II transcription factor bindingPITX1;NR1H4;KLF4;MED12;NOTCH1;PPARA;NFE2L1;NKX2;MIXL1

CREB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB1.

TSSK4; MEIS1; CREBBP; PASK; p03259-2

Matsumura, H; Nakayama, Y; et al. Effects of interleukin-11 on the expression of human bone sialoprotein gene. JOURNAL OF BONE AND MINERAL METABOLISM 33:142-153(2015).
Matsumura, H; Ogata, Y; et al. Melatonin regulates human bone sialoprotein gene transcription. JOURNAL OF ORAL SCIENCE 56:67-76(2014).
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