DUT
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Official Full Name
deoxyuridine triphosphatase
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Overview
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. -
Synonyms
DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622; DYNLL1; dynein, light chain, LC8-type 1; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1; MGC126137; MGC126138; dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase; Dynein light chain LC8-type 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Canis lupus
- Chicken
- Human
- Mouse
- Rat
- Streptomyces coelicolor A3(2)
- Zebrafish
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
DUT involved in several pathways and played different roles in them. We selected most pathways DUT participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolic pathways | CYP27B1;ATP6AP1;PI4KAA;BCKDHB;INPP5E;NAGK;POLR2K;KCNG4;AK7 |
Metabolism | ADA;CYP4B1;CHST9;MARCKSA;AKR1C4;CBLC-1;NDUFAF3;APOF;MED16 |
Metabolism of nucleotides | PAICS;NUDT16;GLRX;TYMP;ADAL;ADK;GRX2;NUDT18;NUDT5 |
Pyrimidine biosynthesis | DUT;DHODH |
Pyrimidine metabolism | NT5C1B-RDH14;DPYDB;DCK;RRM2B;TYMP;DCTPP1;UCK2B;PNP6;CANT1B |
pyrimidine deoxyribonucleotides de novo biosynthesis | DTYMK;DUT |
pyrimidine deoxyribonucleotides de novo biosynthesis I | |
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | DUT;CMPK2 |
DUT has several biochemical functions, for example, dUTP diphosphatase activity, magnesium ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUT itself. We selected most functions DUT had, and list some proteins which have the same functions with DUT. You can find most of the proteins on our site.
Function | Related Protein |
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dUTP diphosphatase activity | |
magnesium ion binding | PRKACB;IRAK4;PKM2;FOXK2;NLK;ENO3;ALPI;TOP2A;RPS6KA2 |
poly(A) RNA binding | HIST1H1D;DNAJC2;HIST1H4K;COA6;GNL2;SAP18;NOP2;PTPN1;YTHDF3 |
protein binding | MRPL28;TPPP;VMP1;TNNC2;PRLR;NUDT22;TSHR;GPR177;PEX1 |
DUT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUT here. Most of them are supplied by our site. Hope this information will be useful for your research of DUT.
NUDT18; PLEKHF2; GH1; PINX1; RHOB; parE; q81k60_bacan; recN; ypdA; q81v76_bacan; yacO; q8cki1_yerpe; clpA3; fadB; cysJ; panE; epmA
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, alterations in the expression levels of the DUT protein can serve as a biomarker for certain cancers, aiding in early diagnosis and prognosis.
Research suggests a link between the DUT protein and neurodegenerative diseases, where its dysfunction may impact DNA repair processes in neurons, potentially contributing to disease progression.
Research suggests that the DUT protein is particularly relevant in colorectal cancer, where its abnormal expression may impact DNA replication and repair mechanisms.
The DUT protein is implicated in cancer research as its dysregulation can lead to an imbalance in nucleotide pools, potentially contributing to genomic instability, a common feature in cancer cells.
Understanding the role of the DUT protein helps in developing targeted therapies that aim to modulate its activity, potentially disrupting cancer cell proliferation.
Customer Reviews (3)
Write a reviewThe DUT protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.
Another advantage of the DUT protein is its reliability and consistency, ensuring robust and reproducible results.
Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.
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