EPO
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Official Full Name
erythropoietin
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Overview
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] -
Synonyms
EPO; erythropoietin; EP; MVCD2; epoetin;
- Recombinant Proteins
- GMP Proteins
- Therapeutic Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Assay Kits
- Bovine
- Canine
- Cynomolgus
- Cynomolgus monkey
- Dog
- Equine
- Horse
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- Rhesus monkey
- Rhesusmacaque
- Zebrafish
- CHO
- CHO-K1
- E.coli
- HEK293
- HEK293F
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Insect cells
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Fc
- His
- GST
- hFc
- His (Fc)
- Avi
- Myc
- His|GST
- His|S
- His|T7
- B2M
- SUMO
- N/A
- N
- MBP
- Strep II
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- EPO Related Articles
- EPO Related Research Area
- EPO Related Signal Pathway
EPO involved in several pathways and played different roles in them. We selected most pathways EPO participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CXCL11;IL20RB;IL10RA;TGFBR2;TNFRSF9;BMPR2;Ifna15;CRLF2;TGFB3 |
HIF- signaling pathway | EPO;HIF1A;IL6R;EIF4E2;Il6ra;TFRC;TIMP1;INS1;ERBB2 |
PIK-Akt signaling pathway | PIK3CB;PPP2R2B;IFNAR2;IL2RG;PRLR;Fasl;ITGA6;ITGA2B;IFNA5 |
Jak-STAT signaling pathway | LIF;IFNL3;IFNGR2;GH2;IL2RG;SOCS5B;IFNB;IFNA12;RNF207B |
Hematopoietic cell lineage | IL5;CD59;Flt3l;CD1d1;IL5RA;CD8B1;HLA-DRB1;ANPEP;ITGA1 |
EPO has several biochemical functions, for example, erythropoietin receptor binding, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPO itself. We selected most functions EPO had, and list some proteins which have the same functions with EPO. You can find most of the proteins on our site.
Function | Related Protein |
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erythropoietin receptor binding | EPO;RNF41 |
hormone activity | INHBC;METRNL;FAM132A;PRL8A8;SMTLB;INSL5;GNRH1;LHB;INSL5B |
protein binding | SWSAP1;VSNL1;DCAF12L1;SMARCAD1;CUL2;TSPAN4;PABPC1;HDDC2;BTN3A1 |
protein kinase activator activity | MAPK8IP2;PIK3CA;CAB39;TOM1L1;PRKAG2;DUSP19;EPO;MT3;NKX3 |
EPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPO here. Most of them are supplied by our site. Hope this information will be useful for your research of EPO.
EPOR; DOK2; EP300
- Q&As
- Reviews
Q&As (6)
Ask a questionEPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.
By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.
EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.
The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.
This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.
In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.
Customer Reviews (3)
Write a reviewStability is truly remarkable, can maintain its activity even under extreme conditions.
Can catalyze reactions even under extreme conditions.
This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.
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