GH
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Official Full Name
Growth Hormone
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Overview
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. -
Synonyms
GH; IGHD1B; GH-N; Somatotropin; GHN; Growth hormone; hGH-N; GH1; HGH;
- Recombinant Proteins
- Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
- Bream
- Carp
- Cattle
- Chicken
- Denis
- Dog
- EBV
- Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
- Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
- Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
- Equine herpesvirus 2 (strain 86/87) (EHV-2)
- Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
- Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
- Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
- Guinea pig cytomegalovirus (strain 22122) (GPCMV)
- HHV-3(strain Oka vaccine)
- HHV-5
- Human
- Human cytomegalovirus
- Human herpesvirus 3
- Human herpesvirus 4
- Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
- Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
- Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
- Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
- Mai Mai
- Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
- Mouse
- Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
- Ovine
- Pig
- Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
- Rabbit
- Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
- Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
- Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Nicotiana Benthamiana
- Yeast
- His
- Myc
- SUMO
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | GH-2744H | Active Recombinant Human Growth Hormone 1 | Nicotiana Benthamiana | N/A | ||
Human | GH-66H | Recombinant Human Growth Hormone Placental 20K | E.coli | N/A | ||
Mouse | GH-04M | Recombinant Mouse Growth Hormone | E.coli | N/A | ||
Mouse | Gh-783M | Recombinant Mouse Gh protein, His-tagged | E.coli | His | Pro28~Phe216 | |
Mouse | Gh-067M | Recombinant Mouse Gh Protein | E.coli | |||
Mouse | GH-1251M | Recombinant Mouse GH protein, His&hFc-tagged | HEK293 | His | Phe27~Phe216 | |
Rabbit | GH-40R | Recombinant Rabbit Growth Hormone | E.coli | N/A | ||
Dog | GH-1252D | Recombinant Dog GH protein, His-tagged | HEK293 | His | Phe27~Phe216 | |
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) | RFL25197AF | Recombinant Full Length Alcelaphine Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (15-733) | |
Bream | GH-780B | Recombinant Bream GH Protein | E.coli | N/A | ||
Carp | GH-29C | Recombinant Carp Growth Hormone | E.coli | N/A | ||
Cattle | GH-1256C | Recombinant Cattle GH protein, His-tagged | HEK293 | His | Ala27~Phe217 | |
Denis | GH-32D | Recombinant Denis Growth Hormone | E.coli | N/A | ||
EBV | gH-339V | Recombinant EBV(Strain B95-8) gH (Ectodomain) Protein, His-tagged | HEK293 | His | ||
Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus) | RFL1167EF | Recombinant Full Length Elephantid Herpesvirus 1 Glycoprotein H Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (26-737) | |
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) | RFL24305EF | Recombinant Full Length Epstein-Barr Virus Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-706) | |
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) | RFL36517EF | Recombinant Full Length Epstein-Barr Virus Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-706) | |
Equine herpesvirus 2 (strain 86/87) (EHV-2) | RFL8540EF | Recombinant Full Length Equine Herpesvirus 2 Glycoprotein H(22) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-763) | |
Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus) | RFL14428FF | Recombinant Full Length Feline Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (22-821) | |
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) | RFL7374GF | Recombinant Full Length Gallid Herpesvirus 2 Envelope Glycoprotein H(Mdv034) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-813) | |
Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1) | RFL20150GF | Recombinant Full Length Gallid Herpesvirus 2 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-813) | |
Guinea pig cytomegalovirus (strain 22122) (GPCMV) | RFL27671GF | Recombinant Full Length Guinea Pig Cytomegalovirus Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-723) | |
HHV-3(strain Oka vaccine) | gH-4273H | Recombinant HHV-3(strain Oka vaccine) gH protein, His-tagged | E.coli | His | 243-611aa | |
HHV-5 | gH-5591H | Recombinant HHV-5 gH protein, His-tagged | Yeast | His | 24-195aa | |
Human cytomegalovirus | gH-3847H | Recombinant Human cytomegalovirus gH protein, His-SUMO-tagged | E.coli | His-SUMO | 24-195aa | |
Human herpesvirus 3 | gH-5965H | Recombinant Human herpesvirus 3 gH protein, His&Myc-tagged | E.coli | His&Myc | 18-317aa | |
Human herpesvirus 4 | gH-4262H | Recombinant Human herpesvirus 4 gH protein, His-SUMO-tagged | E.coli | His-SUMO | 19-218aa | |
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus) | RFL5317HF | Recombinant Full Length Human Herpesvirus 6A Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-694) | |
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) | RFL16786HF | Recombinant Full Length Human Herpesvirus 6A Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (17-694) | |
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) | RFL20156HF | Recombinant Full Length Human Herpesvirus 6B Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (17-694) | |
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) | RFL28270HF | Recombinant Full Length Human Herpesvirus 7 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (17-690) | |
Mai Mai | GH-33M | Recombinant Mai Mai Growth Hormone | E.coli | N/A | ||
Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus) | RFL26349MF | Recombinant Full Length Meleagrid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-808) | |
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) | RFL33736MF | Recombinant Full Length Murid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (15-725) | |
Ovine | GH-5426O | Recombinant Ovine Growth Hormone, Ultra Pure | E.coli | N/A | ||
Ovine | GH-36O | Recombinant Ovine Growth Hormone, Antagonist | E.coli | N/A | ||
Ovine | GH-35O | Recombinant Ovine Growth Hormone | E.coli | N/A | ||
Ovine | GH-181O | Recombinant Ovine Placental Growth Hormone | E.coli | N/A | ||
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) | RFL28848PF | Recombinant Full Length Psittacid Herpesvirus 1 Envelope Glycoprotein H(Ul22) Protein, His-Tagged | E.coli expression system | His | Full Length (41-806) | |
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) | RFL24724SF | Recombinant Full Length Saimiriine Herpesvirus 2 Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (17-717) | |
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan)) | RFL24201SF | Recombinant Full Length Suid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length (31-686) | |
Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice)) | RFL17136SF | Recombinant Full Length Suid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged | E.coli expression system | His | Full Length (31-686) | |
Pig | GH-37P | Recombinant Porcine Growth Hormone | E.coli | N/A | ||
Pig | GH-1255P | Recombinant Pig GH protein, His&hFc-tagged | HEK293 | His | Phe27~Phe216 | |
Chicken | GH-5930C | Recombinant Chicken GH | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
GH involved in several pathways and played different roles in them. We selected most pathways GH participated on our site, such as Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neuroactive ligand-receptor interaction | P2RX1;GABRB1;GABRB2;P2RY4;GABRA1;GALR1;PTGER1C;NPBWR1;PRP2 |
PIK-Akt signaling pathway | MTOR;COL6A6;PKN1;Il6ra;EPOR;GNB2;Ifna11;TLR2;COL4A1 |
Jak-STAT signaling pathway | TSLP;TP-1;PTPN11;AOX1;GH1;OSM;IFNPHI1;IFNL3;STAT1B |
GH has several biochemical functions, for example, growth hormone receptor binding, hormone activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GH itself. We selected most functions GH had, and list some proteins which have the same functions with GH. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
growth hormone receptor binding | JAK1;GH1;Gh;SOCS2;TYK2;JAK2 |
hormone activity | LHB;NPPC;PTH1A;AGT;GCGB;BMP10;PRL3B1;INSL4;C1QTNF9 |
metal ion binding | UPB1;ACSM1;RORCA;COPS5;NRXN3A;PDE8B;TH2;IDO2;HPDL |
GH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH here. Most of them are supplied by our site. Hope this information will be useful for your research of GH.
Ywhae
- Q&As
- Reviews
Q&As (6)
Ask a questionIn the treatment of certain diseases, such as growth hormone deficiency and dwarfism, replacement therapy can be achieved with the use of GH protein or its analogues to promote the growth and development of the body.
Studying the regulation of gene expression of GH protein can be achieved through the study of gene transcription, post-transcriptional modification, and translation. For example, it can be done by detecting the expression and activity of transcription factors, or by studying the effects of epigenetic modifications on GH gene expression.
There are complex interactions between GH protein and other hormones. For example, GH protein can stimulate the secretion of insulin-like growth factor-1 (IGF-1), which in turn regulates GH secretion. In addition, GH can also interact with sex hormones to affect the body's growth and metabolic processes.
In clinical practice, the diagnosis of diseases such as growth hormone deficiency, gigantism, and acromegaly can be guided by detecting the level or gene sequence of GH protein, as well as stimulation tests on GH protein. At the same time, based on the structural and functional characteristics of GH proteins, new drugs can be developed to treat these diseases.
The diagnosis of growth hormone deficiency requires a series of laboratory tests, including GH stimulation test, insulin tolerance test, and serum insulin-like growth factor-1 (IGF-1) level. These tests can help your doctor determine whether you have a growth hormone deficiency.
The structure and function of GH proteins are closely related. Its specific amino acid sequence and spatial conformation determine its ability to bind to receptors and activate receptors. Therefore, the understanding of the structure and function of GH protein can help in the development of new drug designs and treatments.
Customer Reviews (3)
Write a reviewDue to its high activity, the experiment can be successful in the first time, reducing the number of experiments.
Fluorescent labeling works well and helps with imaging studies.
The high yield and high purity facilitate our large-scale experiments.
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