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GH

  • Official Full Name

    Growth Hormone

  • Overview

    The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
  • Synonyms

    GH; IGHD1B; GH-N; Somatotropin; GHN; Growth hormone; hGH-N; GH1; HGH;

  • Recombinant Proteins
  • Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
  • Bream
  • Carp
  • Cattle
  • Chicken
  • Denis
  • Dog
  • EBV
  • Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)
  • Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
  • Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
  • Equine herpesvirus 2 (strain 86/87) (EHV-2)
  • Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
  • Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
  • Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
  • Guinea pig cytomegalovirus (strain 22122) (GPCMV)
  • HHV-3(strain Oka vaccine)
  • HHV-5
  • Human
  • Human cytomegalovirus
  • Human herpesvirus 3
  • Human herpesvirus 4
  • Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
  • Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
  • Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
  • Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
  • Mai Mai
  • Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
  • Mouse
  • Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
  • Ovine
  • Pig
  • Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
  • Rabbit
  • Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
  • Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
  • Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Nicotiana Benthamiana
  • Yeast
  • His
  • Myc
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GH-2744H Active Recombinant Human Growth Hormone 1 Nicotiana Benthamiana N/A
Human GH-66H Recombinant Human Growth Hormone Placental 20K E.coli N/A
Mouse GH-04M Recombinant Mouse Growth Hormone E.coli N/A
Mouse Gh-783M Recombinant Mouse Gh protein, His-tagged E.coli His Pro28~Phe216
Mouse Gh-067M Recombinant Mouse Gh Protein E.coli
Mouse GH-1251M Recombinant Mouse GH protein, His&hFc-tagged HEK293 His Phe27~Phe216
Rabbit GH-40R Recombinant Rabbit Growth Hormone E.coli N/A
Dog GH-1252D Recombinant Dog GH protein, His-tagged HEK293 His Phe27~Phe216
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) RFL25197AF Recombinant Full Length Alcelaphine Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (15-733)
Bream GH-780B Recombinant Bream GH Protein E.coli N/A
Carp GH-29C Recombinant Carp Growth Hormone E.coli N/A
Cattle GH-1256C Recombinant Cattle GH protein, His-tagged HEK293 His Ala27~Phe217
Denis GH-32D Recombinant Denis Growth Hormone E.coli N/A
EBV gH-339V Recombinant EBV(Strain B95-8) gH (Ectodomain) Protein, His-tagged HEK293 His
Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus) RFL1167EF Recombinant Full Length Elephantid Herpesvirus 1 Glycoprotein H Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-737)
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) RFL24305EF Recombinant Full Length Epstein-Barr Virus Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-706)
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) RFL36517EF Recombinant Full Length Epstein-Barr Virus Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-706)
Equine herpesvirus 2 (strain 86/87) (EHV-2) RFL8540EF Recombinant Full Length Equine Herpesvirus 2 Glycoprotein H(22) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-763)
Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus) RFL14428FF Recombinant Full Length Feline Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-821)
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) RFL7374GF Recombinant Full Length Gallid Herpesvirus 2 Envelope Glycoprotein H(Mdv034) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-813)
Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1) RFL20150GF Recombinant Full Length Gallid Herpesvirus 2 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-813)
Guinea pig cytomegalovirus (strain 22122) (GPCMV) RFL27671GF Recombinant Full Length Guinea Pig Cytomegalovirus Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-723)
HHV-3(strain Oka vaccine) gH-4273H Recombinant HHV-3(strain Oka vaccine) gH protein, His-tagged E.coli His 243-611aa
HHV-5 gH-5591H Recombinant HHV-5 gH protein, His-tagged Yeast His 24-195aa
Human cytomegalovirus gH-3847H Recombinant Human cytomegalovirus gH protein, His-SUMO-tagged E.coli His-SUMO 24-195aa
Human herpesvirus 3 gH-5965H Recombinant Human herpesvirus 3 gH protein, His&Myc-tagged E.coli His&Myc 18-317aa
Human herpesvirus 4 gH-4262H Recombinant Human herpesvirus 4 gH protein, His-SUMO-tagged E.coli His-SUMO 19-218aa
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus) RFL5317HF Recombinant Full Length Human Herpesvirus 6A Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-694)
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) RFL16786HF Recombinant Full Length Human Herpesvirus 6A Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-694)
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) RFL20156HF Recombinant Full Length Human Herpesvirus 6B Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-694)
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) RFL28270HF Recombinant Full Length Human Herpesvirus 7 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-690)
Mai Mai GH-33M Recombinant Mai Mai Growth Hormone E.coli N/A
Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus) RFL26349MF Recombinant Full Length Meleagrid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-808)
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) RFL33736MF Recombinant Full Length Murid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (15-725)
Ovine GH-5426O Recombinant Ovine Growth Hormone, Ultra Pure E.coli N/A
Ovine GH-36O Recombinant Ovine Growth Hormone, Antagonist E.coli N/A
Ovine GH-35O Recombinant Ovine Growth Hormone E.coli N/A
Ovine GH-181O Recombinant Ovine Placental Growth Hormone E.coli N/A
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) RFL28848PF Recombinant Full Length Psittacid Herpesvirus 1 Envelope Glycoprotein H(Ul22) Protein, His-Tagged E.coli expression system His Full Length (41-806)
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) RFL24724SF Recombinant Full Length Saimiriine Herpesvirus 2 Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-717)
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan)) RFL24201SF Recombinant Full Length Suid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length (31-686)
Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice)) RFL17136SF Recombinant Full Length Suid Herpesvirus 1 Envelope Glycoprotein H(Gh) Protein, His-Tagged E.coli expression system His Full Length (31-686)
Pig GH-37P Recombinant Porcine Growth Hormone E.coli N/A
Pig GH-1255P Recombinant Pig GH protein, His&hFc-tagged HEK293 His Phe27~Phe216
Chicken GH-5930C Recombinant Chicken GH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GH involved in several pathways and played different roles in them. We selected most pathways GH participated on our site, such as Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGRIN2B;NPFFR1L2;GRIN2A;CHRNA3;NTSR1;OPRM1;PTGER1A;GABRR1;MC3R
PIK-Akt signaling pathwayINS2;Ifna11;RPTOR;Il2;SYK;IL7;MTOR;ITGB7;HRAS
Jak-STAT signaling pathwayIL6;EP300;IL20;TP-1;GRB2A;PRL;IL9;RAF1;PIM1

GH has several biochemical functions, for example, growth hormone receptor binding, hormone activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GH itself. We selected most functions GH had, and list some proteins which have the same functions with GH. You can find most of the proteins on our site.

Function Related Protein
growth hormone receptor bindingJAK1;SOCS2;JAK2;TYK2;Gh;GH1
hormone activityUCN2;RLN2;INSL5;SCT;UTS2D;PRL8A9;GCG;GUCA2A;CRH
metal ion bindingZNF804A;BIRC5;ACVRL1;IDO2;ZMYM2;PFKM;CUBN;ZBTB4;PTGS1

GH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH here. Most of them are supplied by our site. Hope this information will be useful for your research of GH.

Ywhae

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How to use growth hormone protein to treat disease? 07/07/2021

In the treatment of certain diseases, such as growth hormone deficiency and dwarfism, replacement therapy can be achieved with the use of GH protein or its analogues to promote the growth and development of the body.

How can the regulation of GH protein gene expression be studied? 10/18/2020

Studying the regulation of gene expression of GH protein can be achieved through the study of gene transcription, post-transcriptional modification, and translation. For example, it can be done by detecting the expression and activity of transcription factors, or by studying the effects of epigenetic modifications on GH gene expression.

Can growth hormone proteins interact with other hormones? 09/08/2020

There are complex interactions between GH protein and other hormones. For example, GH protein can stimulate the secretion of insulin-like growth factor-1 (IGF-1), which in turn regulates GH secretion. In addition, GH can also interact with sex hormones to affect the body's growth and metabolic processes.

How can information from GH proteins be used to guide diagnosis or therapy in clinical practice? 05/05/2020

In clinical practice, the diagnosis of diseases such as growth hormone deficiency, gigantism, and acromegaly can be guided by detecting the level or gene sequence of GH protein, as well as stimulation tests on GH protein. At the same time, based on the structural and functional characteristics of GH proteins, new drugs can be developed to treat these diseases.

What laboratory tests are used to diagnose growth hormone deficiency? 01/26/2020

The diagnosis of growth hormone deficiency requires a series of laboratory tests, including GH stimulation test, insulin tolerance test, and serum insulin-like growth factor-1 (IGF-1) level. These tests can help your doctor determine whether you have a growth hormone deficiency.

Are the structure and function of GH proteins related? 12/28/2019

The structure and function of GH proteins are closely related. Its specific amino acid sequence and spatial conformation determine its ability to bind to receptors and activate receptors. Therefore, the understanding of the structure and function of GH protein can help in the development of new drug designs and treatments.

Customer Reviews (3)

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Reviews
01/20/2022

    Due to its high activity, the experiment can be successful in the first time, reducing the number of experiments.

    11/17/2020

      Fluorescent labeling works well and helps with imaging studies.

      09/22/2020

        The high yield and high purity facilitate our large-scale experiments.

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