Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

KCNH2

Official Full Name

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2
Overview

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
Synonyms

KCNH2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1; potassium voltage-gated channel subfamily H member 2; ERG-1; H-ERG; hERG-1; eag homolog; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; ether-a-go-go-related potassium channel protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Cavia porcellus (Guinea pig)
Human
Rat
Sus scrofa (Pig)

Source

E.coli expression system
HEK293
Mammalian cell
Mammalian Cell

Tag

C
10×His
eGFP
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNH2-5059HCL	Recombinant Human KCNH2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KCNH2-15H	Recombinant Human KCNH2-3C-eGFP Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), C-10×His-tagged	Mammalian cell	C-10×His	M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005	Inquiry
Human	KCNH2-0838H	Recombinant Human KCNH2 Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), eGFP tagged	Mammalian cell	eGFP	M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005	Inquiry
Rat	KCNH2-3183R	Recombinant Rat KCNH2 Protein	Mammalian Cell	His		Inquiry
Rat	KCNH2-2839R-B	Recombinant Rat KCNH2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KCNH2-2839R	Recombinant Rat KCNH2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cavia porcellus (Guinea pig)	RFL1218CF	Recombinant Full Length Guinea Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-162)	Inquiry
Sus scrofa (Pig)	RFL20356SF	Recombinant Full Length Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-97)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
KCNH2 Related Articles

KCNH2 involved in several pathways and played different roles in them. We selected most pathways KCNH2 participated on our site, such as Neuronal System, Potassium Channels, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neuronal System	SLC6A12;SLC1A3A;KCNK18;DLG3;KCNK1A;SYN1;KCNQ2;GJA10;GLS2B
Potassium Channels	KCNK3A;KCNK13B;KCNN2;KCNB1;KCNA4;KCNAB1A;KCNH1;KCNAB2;KCNH8
SIDS Susceptibility Pathways	KCNQ1;GATA2;FOXM1;CC2D1A;TAC1;PLP1;CTCF;ASCL1;KCNJ8
Voltage gated Potassium channels	KCNH8;KCNC1B;KCNAB1A;KCNH5A;KCNH6;KCNG3;KCNS2;KCND1;KCND2

KCNH2 has several biochemical functions, for example, C3HC4-type RING finger domain binding, delayed rectifier potassium channel activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH2 itself. We selected most functions KCNH2 had, and list some proteins which have the same functions with KCNH2. You can find most of the proteins on our site.

Function	Related Protein
C3HC4-type RING finger domain binding	HSPA1B;PINK1;KCNH2;HSPA1A;DNAJA1;HSPA8
delayed rectifier potassium channel activity	KCNG4A;KCNV2;KCNC3B;KCNA1;KCNC4;KCNQ3;KCNA2B;KCNA6;KCNC1B
identical protein binding	UAP1;SMAD3;BCL2;ZNHIT6;KCTD17;HOOK2;SH3GL1;CLDNG;OMG
inward rectifier potassium channel activity	KCNJ14;KCNJ1;KCNK6;KCNJ2;KCNJ16;KCNQ5;KCNJ8;KCNJ6;KCNJ11L
phosphorelay sensor kinase activity	KCNH1B;KCNH5;CASS4;KCNH1;KCNH2;KCNH1A;KCNH8;KCNH5A
protein binding	TNFRSF14;CDK16;HIST1H3D;NHLRC2;PPP2R5A;FANCB;MORF4L2;IGFBP2;DZIP1L
protein homodimerization activity	XCL1;NACC2;PVRL2L;OXCT1;TPR;CCDC103;PDGFRA;PRLR;CBLN1
scaffold protein binding	NLGN4X;PARK7;SRC;NCK2;NLGN4Y;CRIPT;TREM2;NLGN1;CHRNA7
ubiquitin protein ligase binding	TMEM189;UBXN1;JKAMP;RELA;TXNIP;MYOD1;KCNH2;PRKACB;CUL4A
voltage-gated potassium channel activity	CNGA2;KCNH5A;KCNJ11;KCNAB2;KCNMA1A;KCNK5;KCNB2;KCNAB1A;KCNH6A
contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	KCNE1;KCNE1L;KCNH2
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCNE2;KCNH2;KCNQ1

KCNH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH2.

CAV1; PASK; NDUFS6; ARHH; CDC73; GABARAP; MAP1LC3B

Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).

Wulff, H; Castle, NA; et al. Voltage-gated potassium channels as therapeutic targets. NATURE REVIEWS DRUG DISCOVERY 8:982-1001(2009).