hly
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Overview
The secreted pore-forming protein listeriolysin O (LLO) is an essential virulence determinant of the facultative intracellular bacterium Listeria monocytogenes that allows the pathogen to escape from the phagocytic vacuole and reach the host cytosol. LLO is a single polypeptide protein encoded by the hlyA gene and composed of 529 residues. At its NH2-terminus it possesses a 25 residues long typical signal sequence excited during the secretion process. Moreover, in its NH2-terminus there is also a 19 amino acids PEST- like sequence that may target this toxin for degradation. This motif seems to be essential for bacterial virulence too, since its deletion causes a defect in bacterium phagosomal escaping. -
Synonyms
Hly;listeriolysin O;identified by similarity to SP:P13128;match to protein family HMM PF01289;
- Recombinant Proteins
- Listeria monocytogenes
- Listeria monocytogenes serotype 1/2a (strain 08-5923)
- S. alpha
- Staphylococcus Aureus
- E.coli
- Yeast
- C
- His
- His|SUMO
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Listeria monocytogenes | hly-241 | Active Recombinant Listeria monocytogenes hly protein | E.coli | N/A | ||
Listeria monocytogenes | hly-5586L | Recombinant Listeria monocytogenes hly Protein (Asp26-Glu529), C-His tagged | E.coli | C-His | Asp26-Glu529 | |
Listeria monocytogenes serotype 1/2a (strain 08-5923) | hly-5680L | Recombinant Listeria monocytogenes serotype 1/2a hly Protein (Asp26-Glu529), C-His tagged | E.coli | C-His | Asp26-Glu529 | |
S. alpha | HLY-01S | Recombinant Active S. alpha HLY protein | E.coli | |||
Staphylococcus Aureus | HLY-1666S | Recombinant Staphylococcus Aureus HLY Protein (27-319 aa), His-tagged | Yeast | His | 27-319 aa | |
Staphylococcus Aureus | HLY-1020S | Recombinant Staphylococcus Aureus HLY Protein (27-319 aa), His-SUMO-tagged | E.coli | His/SUMO | 27-319 aa | |
hly-243 | Active Recombinant Listeriolysin O, PEST Free | E.coli | N/A |
hly involved in several pathways and played different roles in them. We selected most pathways hly participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with hly were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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hly has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by hly itself. We selected most functions hly had, and list some proteins which have the same functions with hly. You can find most of the proteins on our site.
Function | Related Protein |
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hly has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hly here. Most of them are supplied by our site. Hope this information will be useful for your research of hly.
- Q&As
- Reviews
Q&As (5)
Ask a questionHLY protein can be used in various diseases, including infectious diseases, genetic disorders, and neurological conditions.
Yes, it can be used to deliver chemotherapy drugs directly to cancer cells.
Yes, it can be used in diagnostic assays to detect specific cells or molecules in clinical samples.
HLY protein can be engineered to create pores in the membranes of specific cells, allowing drugs to enter these cells more effectively.
HLY protein has several clinical applications due to its ability to create pores in cell membranes.
Customer Reviews (3)
Write a reviewWhether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.
The combination of exceptional quality, reliable performance, and dedicated customer service makes them an invaluable partner in my research journey.
Their proactive approach ensures that I am always working with the latest advancements in HLY protein research, allowing me to explore new avenues and potentially uncover groundbreaking discoveries.
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