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MASP1

  • Official Full Name

    mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)

  • Overview

    This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
  • Synonyms

    MASP1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); CRARF, mannan binding lectin serine protease 1 (C4/C2 activating component of Ra reactive factor) , PRSS5; mannan-binding lectin serine protease 1; MASP; Complement factor MASP-3; Complement factor MASP3; Complement-activating component of Ra-reactive factor; CRARF; Mannose binding lectin associated serine protease 1; Mannose binding protein associated serine protease; Mannose-binding lectin-associated serine protease 1; Mannose-binding lectin-associated serine protease-1; PRSS 5; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; OTTHUMP00000209926; OTTHUMP00000209927; OTTHUMP00000209928; OTTHUMP00000209929; OTTHUMP00000209930; mannose-binding protein-associated se; MAP1; MASP3; MAp44; PRSS5; CRARF1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MASP1-138H Active Recombinant Human MASP1 protein, His-tagged Mammalian cells His Ile450-Val721
Human MASP1-137H Recombinant Human MASP1, His-tagged HEK293 His
Human MASP1-754H Recombinant Human MASP1, His-tagged E.coli His 29-321aa
Human MASP1-755H Recombinant Human MASP1, GST-tagged Wheat Germ GST
Human MASP1-4460HCL Recombinant Human MASP1 293 Cell Lysate HEK293 N/A
Human MASP1-4461HCL Recombinant Human MASP1 293 Cell Lysate HEK293 N/A
Human MASP1-1451H Recombinant Human MASP1 Protein (20-699 aa), His-tagged Yeast His 20-699 aa
Human MASP1-3744H Recombinant Human MASP1 Protein (His20-Pro434), N-His tagged E.coli N-His His20-Pro434
Human MASP1-1372H-B Recombinant Human MASP1 Protein Pre-coupled Magnetic Beads HEK293
Human MASP1-648H Recombinant Human MASP1 Protein (20-699 aa), His-SUMO-tagged E.coli His/SUMO 20-699 aa
Human MASP1-668HFL Recombinant Full Length Human MASP1 Protein, C-Flag-tagged Mammalian cells Flag
Human MASP1-1372H Recombinant Human MASP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MASP1-3311H Recombinant Human MASP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MASP1-01H Recombinant Human MASP1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human MASP1-4869H Recombinant Human MASP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MASP1-02H Recombinant Human MASP1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human MASP1-3743H Recombinant Human MASP1 Protein (His20-Arg728), C-His tagged Mammalian cells C-His His20-Arg728
Mouse Masp1-1943M Recombinant Mouse Masp1 protein, His-tagged E.coli His His25~Arg453
Mouse MASP1-9576M Recombinant Mouse MASP1 Protein Mammalian Cell His
Mouse MASP1-5379M-B Recombinant Mouse MASP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse MASP1-5379M Recombinant Mouse MASP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Masp1-3966M Recombinant Mouse Masp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MASP1-3592R Recombinant Rat MASP1 Protein Mammalian Cell His
Rat MASP1-3248R Recombinant Rat MASP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MASP1-3248R-B Recombinant Rat MASP1 Protein Pre-coupled Magnetic Beads HEK293
Chicken MASP1-7139C Recombinant Chicken MASP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MASP1 Related Articles
  • MASP1 Related Research Area

MASP1 involved in several pathways and played different roles in them. We selected most pathways MASP1 participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSERPINC1;SERPINA1D;MASP2;FGB;C1S;PROS1;C6;SERPINE1;THBD
Staphylococcus aureus infectionHLA-DOB;ITGB2;MBL1;C3AR1;C1S;DSG1A;FCAR;HLA-DMA;FCGR3A

MASP1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MASP1 itself. We selected most functions MASP1 had, and list some proteins which have the same functions with MASP1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingNOL3;ACTN3;ADAMTS13;PCDHGB4;PEF1;RCVRN;PCDH1GC6;MYL12B;FKBP14
calcium-dependent protein bindingCPNE3;ANXA3;S100PBP;TNNT3;VPS37B;S100B;VAMP2;TSG101;TNNI3
peptidase activityZRANB1B;ST14A;FURINA;PLAUA;IMMP2L;SPPL3;SPCS3;Casp3;ASTL
protein bindingTMPRSS2;CABLES1;CENPO;MPP1;TNKS2;ZUFSP;CRHR1;BCS1L;INCA1
protein homodimerization activityPYGB;LHPP;TYRP1;RXRB;ENO2;DROSHA;CD4;XCL1;SDS
serine-type endopeptidase activityTMPRSS12;PARLA;CFB;CTSG;C1rb;KLK1B22;F10;PRSS42;C1RA

MASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MASP1.

NCK2; NUDT21; H2AFX; GADD45A; GSK3B; RPS6KA3; MAPK8IP2; MAPK6; UFD1L; RPS6KA6; ERBB3; CDK7; CDC37; AP2M1; ERRFI1

Thiel, S; Jensen, L; et al. Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 169:38-48(2012).
Skjoedt, MO; Hummelshoj, T; et al. Serum concentration and interaction properties of MBL/ficolin associated protein-1. IMMUNOBIOLOGY 216:625-632(2011).
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