Ngf
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Official Full Name
nerve growth factor (beta polypeptide)
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Overview
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this genes expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] -
Synonyms
NGF; nerve growth factor (beta polypeptide); NGFB; HSAN5; Beta-NGF; beta-nerve growth factor; nerve growth factor, beta subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
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- Vulpes vulpes (Red fox)
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- C
- Fc
- His
- Flag
- GST
- His (Fc)
- Avi
- His(C
- ter)
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Ngf Related Articles
- Ngf Related Gene Family
- Ngf Related Research Area
Ngf involved in several pathways and played different roles in them. We selected most pathways Ngf participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ngf were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | ELK1;HSC70;PPM1BB;TNFRSF1A;CASP3A;MKNK2A;FGF11;TAOK3;GNG12 |
Ras signaling pathway | RELA;CALML3;SHOC2;FGF8;PAK7;PLCE1;PLA2G12B;GRIN2B;ABL2 |
Rap signaling pathway | FIGF;FGFR3;PLCB1;ITGA2B;FGF10;PRKCB;PARD6B;GNAQ;FGF4 |
PIK-Akt signaling pathway | CRTC2;IFNAR1;FOXO3;TLR4;PPP2CB;PPP2CA;Gh;ITGB4;FGFR4 |
Apoptosis | TNFRSF1A;DERL3;IKBKB;BCL2L11;PRKAR2B;PLECA;PRKACG;HIST1H1A;DSG2 |
Neurotrophin signaling pathway | KIDINS220;BRAF;NGF;SOS1;CALM1;NFKBIE;MAPK7;MAP3K1;RPS6KA3 |
Inflammatory mediator regulation of TRP channels | GNAS;PLCB3;IGF1;CYP2J6;PRKCH;Adcy4;ACCN3;PRKCG;MAP2K6 |
Ngf has several biochemical functions, for example, growth factor activity, metalloendopeptidase inhibitor activity, nerve growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ngf itself. We selected most functions Ngf had, and list some proteins which have the same functions with Ngf. You can find most of the proteins on our site.
Function | Related Protein |
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growth factor activity | MSTNB;KLK1B3;MACC1;FGF10B;BMP4;TDGF1;NENF;INHBE;WISP3 |
metalloendopeptidase inhibitor activity | LXN;TIMP3;TIMP2;TIMP2A;TIMP2B;TIMP1;WFIKKN2;COL4A3;BST2 |
nerve growth factor receptor binding | NGF;NTF7 |
protein binding | CCDC92;VAMP4;PHYH;RCAN1;DRG2;AMMECR1;BASP1;FBXO46;ODAM |
receptor signaling protein activity | RGS14;RGS12B;RAF1A;DOK2;PLCE1;DOK1;NGF;TGFBR1;DOK5 |
Ngf has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ngf here. Most of them are supplied by our site. Hope this information will be useful for your research of Ngf.
NTRK1; Ngfr; NGFR; SORT1; SORCS3
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that NGF protein plays a role in the occurrence and development of pain. It stimulates the growth and survival of sensory neurons and enhances their ability to transmit signals, thereby increasing pain sensation. In addition, NGF can interact with other pain-related molecules to modulate pain perception and tolerance.
There are a variety of drug development treatments that target NGF proteins and their related signaling pathways, including direct administration of NGF proteins, use of their analogues, or drugs that inhibit its degradation. These treatments are in clinical trials and are expected to provide new options for the treatment of neurological disorders.
NGF proteins interact with target cells by binding to their receptors. It binds to TrkA receptors on the surface of target cells, triggering a series of signal transduction mechanisms that ultimately influence the biological behavior of target cells.
In addition to its important role in the nervous system, NGF proteins can also affect the function of other systems. For example, NGF proteins can affect the function of the immune system, involved in inflammatory responses and the development of autoimmune diseases.
The function of NGF protein in glial cells is mainly to regulate its proliferation, differentiation and apoptosis. In addition, NGF promotes the repair and regeneration of damaged neurons by glial cells.
NGF proteins have a variety of biological activities, including promoting neuronal growth, differentiation, survival, and repair of damage, regulating connections and signaling between neurons, and influencing the function of other systems.
Customer Reviews (3)
Write a reviewHigh catalytic efficiency, high safety and high expression level of the protein make it perform well in many experiments.
The short half-life and high clearance of NGF make it possible to better control the concentration and action time of drugs in the body, so as to better control the therapeutic effect.
This production process of NGF pays attention to the recycling of resources and minimizes waste, which is very consistent with the principle of green production.
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