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TAT

  • Official Full Name

    tyrosine aminotransferase

  • Overview

    This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
  • Synonyms

    TAT; tyrosine aminotransferase; tyrosine aminotransferase, cytosolic; L-tyrosine:2-oxoglutarate aminotransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • HIV
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TAT-2502H Recombinant Human TAT, GST-tagged Wheat Germ GST
Human TAT-932H Recombinant Human TAT Protein, His-tagged E.coli His
Human TAT-1709H Recombinant Human TAT Protein, His-tagged E.coli His
Human TAT-9007H Recombinant Human TAT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TAT-1238HCL Recombinant Human TAT 293 Cell Lysate HEK293 N/A
Human TAT-2157H-B Recombinant Human TAT Protein Pre-coupled Magnetic Beads HEK293
Human TAT-5256H Recombinant Human TAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TAT-999HFL Recombinant Full Length Human TAT Protein, C-Flag-tagged Mammalian cells Flag
Human TAT-2157H Recombinant Human TAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TAT-0055H Recombinant Human TAT Protein HEK293 cells
Mouse Tat-1041M Recombinant Mouse Tat protein, His & T7-tagged E.coli His/T7 Pro190~Lys454 (Accession # Q8QZR1)
Mouse Tat-2115M Recombinant Mouse Tat Protein, His-tagged E.coli N-His Pro190-Lys454
Mouse Tat-6297M Recombinant Mouse Tat Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat TAT-5963R Recombinant Rat TAT Protein Mammalian Cell His
Rat TAT-5622R Recombinant Rat TAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TAT-5622R-B Recombinant Rat TAT Protein Pre-coupled Magnetic Beads HEK293
HIV tat-193H Biotinylated Recombinant HIV tat protein E.coli N/A 86 amino acids
HIV tat-188H Recombinant HIV tat protein Clade-A E.coli N/A
HIV tat-189H Recombinant HIV tat protein Clade-B E.coli N/A 86 amino acids
HIV tat-190H Recombinant HIV tat protein Clade-C E.coli N/A 101 amino acids
HIV tat-191H Recombinant HIV tat protein Clade-D E.coli N/A
Zebrafish TAT-4766Z Recombinant Zebrafish TAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TAT Related Articles

TAT involved in several pathways and played different roles in them. We selected most pathways TAT participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Cysteine and methionine metabolism, Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquinone and other terpenoid-quinone biosynthesisCOQ2;HPDA;COQ7;VKORC1L1;AMOTL1;TAT;COQ6;COQ5;COQ3
Cysteine and methionine metabolismDNMT3AA;MDH2;LDHBA;CBS;GSS;MTAP;MAT2A;DNMT3AB;GCLC
Tyrosine metabolismALDH3B1;GOT2A;MAOB;ADH2-1;HPDA;ALDH3B2;AOX1;MAOA;TYR
Phenylalanine metabolismTAT;AOC2;MAOB;MAOA;GOT1;GM4952;GOT2A;HPD;GOT2
Phenylalanine, tyrosine and tryptophan biosynthesisGOT1;TAT;IL4I1;PAH;GOT2B;GOT2;GOT2A
Metabolic pathwaysMT-ND4;MRI1;POLR2D;B4GALT3;MVDA;ATP6V1E1B;FH1;CYP17A1;NDUFA12
Biosynthesis of amino acidsPGK1;GLULA;ALDOC;SHMT1;PHGDH;GOT2A;MAT2AL;PRPS1L1;ALDOAB

TAT has several biochemical functions, for example, L-phenylalanine:2-oxoglutarate aminotransferase activity, L-tyrosine:2-oxoglutarate aminotransferase activity, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAT itself. We selected most functions TAT had, and list some proteins which have the same functions with TAT. You can find most of the proteins on our site.

Function Related Protein
L-phenylalanine:2-oxoglutarate aminotransferase activityGOT2;TAT;GOT2B;GOT2A;GOT1
L-tyrosine:2-oxoglutarate aminotransferase activity
amino acid bindingAGXT;GCHFR;AARS2;SHMT2;AARS;DDAH2;TH;TAT;KARS
pyridoxal phosphate bindingCSAD;MARC1;TAT;PYGL;PROSC;GOT1;MOCOS;GAD1B;ETNPPL

TAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAT here. Most of them are supplied by our site. Hope this information will be useful for your research of TAT.

Alanen, HI; Walker, KL; et al. Efficient export of human growth hormone, interferon alpha 2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:756-763(2015).
Komarova, EY; Meshalkina, DA; et al. The discovery of Hsp70 domain with cell-penetrating activity. CELL STRESS & CHAPERONES 20:343-354(2015).
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