TGFA
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Official Full Name
transforming growth factor, alpha
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Overview
Transforming growth factors (TGFs) are potent mitogeni c polypeptides. Two classes of TGFs have been identified: TGFα and TGFβ . TGF α is synthesized as a 160 amino acid, trans membrane precursor. The precursor undergoes sequential external proteolytic cleavage, releasing TGFα species ranging in molecular weight from 6-25 kDa. Mature TGFα is an acid- and heat-stable 50 amino acid polypeptide of 5.5 kDa. It is secreted by a variety of transformed cells and tumors, and by a number of embryoni c cells as well as some normal adult tissues including the brain and skin keratinocytes. Mature TGF α is approximately 30% homologous, at the amino acid level, to epidermal growth factor (EGF). TGF α binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor, and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-beta. Transformation of cells, in vitro, by certain viruses including SV40 and polyoma virus, as well as transformation by the activated ras oncogene can lead to increased secretion of TGF α. TGF α may play a role in tumor formation by an autocrine/paracrine mechanism whereby TGFα promotes and sustains the transformed character of the cells from which it is secreted as well as that of neighboring cells. The biological relevance of TGF α in tumor development is supported by reports that multiple molecular weight forms of TGF α may be found in the urine of cancer patients in amounts which differ from those found in normal urine samples. TGF α may also play a role in normal development including wound healing. The major difficulty impeding the investigation of the normal and pathological roles of TGFα in vivo has been the use of activity-based biological assays that do not distinguish between TGFα and other related molecules (e.g., EGF). The TGF α ELISA is highly specific and can detect less than 10 pg/ml of human TGF α in a variety of biological fluids and tissue culture media. -
Synonyms
TFGA; TGF-alpha; protransforming growth factor alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Rabbit
- Rat
- Sheep
- Zebrafish
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human
- Mammalian Cell
- yeast
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TGFA Related Research Area
TGFA involved in several pathways and played different roles in them. We selected most pathways TGFA participated on our site, such as ErbB signaling pathway, Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ErbB signaling pathway | GRB2A;HBEGFA;PAK6B;PTK2AA;GAB1;AREGB;GSK3AA;ELK1;PIK3R3 |
Pathways in cancer | PLCB2;RARA;ITGB1;MMP9;EGLN3;GNGT1;FGFR3;NCOA4;FGF6 |
Renal cell carcinoma | FLCN;MAP2K1;RAF1;AHA-1;FH;ETS1;EGLN2;PAK7;ARNT2 |
Pancreatic cancer | MAPK10;NFKB1;STAT3;RAF1;CDC42;PIK3CB;KRAS;IKBKB;BRCA2 |
Glioma | PDGFB;SOS1;CALM1;HRAS;CAMK2G;CALM4;PIK3CG;PIK3CA;GRB2 |
Prostate cancer | PIK3R3;PDPK1;NKX3;NDRG1;HSP90B1;BAD;INSRR;NFKBIA;GRB2 |
Non-small cell lung cancer | ARAF;MAPK3;RXRB;PLCG2;RXRG;BRAF;MAP2K1;MAP2K2;PIK3R3 |
TGFA has several biochemical functions, for example, epidermal growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFA itself. We selected most functions TGFA had, and list some proteins which have the same functions with TGFA. You can find most of the proteins on our site.
Function | Related Protein |
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epidermal growth factor receptor binding | HBEGFA;AGR2;AREG;ATXN2;VAV3;HBEGF;PLSCR1;MS4A1;TNK2 |
growth factor activity | GH1;MANF;FGF12;FGF20A;IL4;SPAW;NENF;TYMP;FGF16 |
protein binding | GPRASP2;NFATC4;PPP2R3A;UGGT1;RUFY4;PLK2;AURKB;CCDC28A;TSSK4 |
TGFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFA here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFA.
EGFR; SGTA; Magi3; MAGI3; MAGI2; ERBB2; ADAM17; NKD2; Gorasp2
- Q&As
- Reviews
Q&As (7)
Ask a questionIt stimulates cell proliferation and survival, playing a key role in tissue development.
Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.
Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.
TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.
Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.
TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.
TGFA is important in wound healing, promoting the regeneration of skin and other tissues.
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