"8xHis-ProTx-II" Related Products

Synthetic 8xHis-ProTx-II

Cat.No.: TOXPP-520S
Product Overview: This product is a Nav1.7 selective blocker with the formula of C168H250N46O41S8.
Description: ProTx-II (ProTx-2, Protoxin II)is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-IIinhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels. ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM,Nav1.2,Nav1.5andNav1.6with IC50values of 41 nM, 79 nM and 26 nM respectively. It also acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors. 8xHis-ProTx-II is a polyhistidine tagged version of ProTx-II.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: ~5200 g/mol
Protein length: 30
AA Sequence: AA sequence: (His-His-His-His-His-His-His-His)-Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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