"ω-agatoxin-IVA" Related Products

Synthetic ω-agatoxin-IVA

Cat.No.: TOXPP-556S
Product Overview: This product is a blocker of P/Q-type calcium channel (Cav2.1) with the formula of C217H360N68O60S10.
Description: ω-agatoxin-IVA(ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker ofP/Q-type calcium channel (Cav2.1). It has been reported thatω-agatoxin IVAis a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site forω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 5202.48 Da
Protein length: 48
AA Sequence: AA sequence: Lys-Lys-Lys-Cys4-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys12-Lys-Trp-Gly-Gly-Thr-Pro-Cys19-Cys20-Arg-Gly-Arg-Gly-Cys25-Ile-Cys27-Ser-Ile-Met-Gly-Thr-Asn-Cys34-Glu-Cys36-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
Disulfide Bonds: Cys4-Cys20; Cys12-Cys25; Cys19-Cys36; Cys27-Cys34
Purity: > 97 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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