"Charybdotoxin" Related Products

Synthetic Charybdotoxin

Cat.No.: TOXPP-535S
Product Overview: This product is a KCa2+channel blocker with the formula of C176H277N57O55S7.
Description: Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+activated K+channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcit ability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks KCa3.1(IC505 nM), Kv1.2(IC5014 nM), Kv1.3(IC502.6 nM) and Kv1.6(IC502 nM) channels.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4295.90 Da
Protein length: 37
AA Sequence: AA sequence: Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH
Disulfide Bonds: Cys7-Cys28; Cys13-Cys33; Cys17-Cys35
Purity: > 97%
Reconstitution: Water or saline buffer
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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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