"Chlorotoxin" Related Products

Synthetic Chlorotoxin

Cat.No.: TOXPP-565S
Product Overview: This product is a selective blocker of small conductance chloride channels with the formula of C158H249N53O47S11.
Description: Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl–channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl–influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl–channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells makingchlorotoxina promising antitumoral drug and diagnosis tool.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3995.8 Da
Protein length: 36
AA Sequence: AA sequence: Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2
Disulfide Bonds: Cys2-Cys19; Cys5-Cys28; Cys16-Cys33; Cys20-Cys35
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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