"α-conotoxin-IMI" Related Products

Synthetic α-conotoxin-IMI

Cat.No.: TOXPP-573S
Product Overview: This product is a α7 nAChR selective blocker with the formula of C52H78N20O15S4.
Description: α-conotoxin IMI (alpha-conotoxin IMI) is aconopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50~ 200 nM). It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 1352.92 Da
Protein length: 12
AA Sequence: AA sequence: Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2
Disulfide Bonds: Cys2-Cys8; Cys3-Cys12
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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