"α-conotoxin-PeIA" Related Products

Synthetic α-conotoxin-PeIA

Cat.No.: TOXPP-567S
Product Overview: This synthetic α-conotoxin-PeIA has the formula of C65H98N22O21S4.
Description: α-conotoxin PeIA is aconotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50of 97 nM) and block voltage-gated N-type Ca2+channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µMα-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 1651.9 Da
Protein length: 16
AA Sequence: AA sequence: Gly-Cys2-Cys3-Ser-His-Pro-Ala-Cys8-Ser-Val-Asn-His-Pro-Glu-Leu-Cys16-NH2
Disulfide Bonds: Cys2-Cys8; Cys3-Cys16
Purity: > 99 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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