"α-Conotoxin PIA" Related Products

Synthetic α-Conotoxin PIA

Cat.No.: TOXPP-576S
Product Overview: This synthetic α-Conotoxin PIA has the formula of C79H125N27O25S4.
Description: α-conotoxin PIA has been isolated from the venom of the marine snail Conus purpurascens. α-conotoxin PIA preferentially targets neuronal AChR subtypes containing α6 subunits. The peptide displays 75-fold higher affinity for rat α6/α3β2β3 nAChRs over rat α3β2 nAChRs. α-conotoxin PIA potently inhibits human chimeric α6/α3β2β3 nAChRs (IC50of 1.7 nM) and provided similar results on rat chimeric α6/α3β2β3 (IC50of 0.95 nM). 10 μMα-conotoxin PIA has no effect on the adult form of the human muscle nAChR demonstrating a high specificity for α6-containing neuronal nAChRs. The peptide has no effect on α2- and α4-containing neuronal nAChRs. α6-containing neuronal nAChRs are highly expressed in several catecholaminergic nuclei (locus coeruleus, ventral tegmental area and substantia nigra), play a significant role in nicotinic reward and dependence, and is a therapeutic target of interest in Parkinson disease.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 1981.29 g/mol
AA Sequence: AA sequence: RDPCCSNPVCTVHNPQIC-NH2
Disulfide Bonds: Cys4-Cys10; Cys5-Cys18
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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