"GaTx2" Related Products

Synthetic GaTx2

Cat.No.: TOXPP-566S
Product Overview: This product is a selective blocker of ClC2 (CLCN2) chloride channels with the formula of C125H199N39O47S6.
Description: GaTx2(gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus.GaTx2is the most potent peptide inhibitor ofClC-2 (CLCN2) chloride channelever described. Kdvalue is close to 20 pM.GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally,GaTx2is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3191.25 Da
Protein length: 29
AA Sequence: AA sequence: Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH
Disulfide Bonds: Cys3-Cys19; Cys6-Cys24; Cys10-Cys26
Purity: > 98 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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