"GsAF-2" Related Products

Synthetic GsAF-2

Cat.No.: TOXPP-531S
Product Overview: This product is a blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7 with the formula of C176H261N47O45S7.
Description: GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3979.78 Da
Protein length: 31
AA Sequence: AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Ile-Glu-Trp-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
Purity: > 98%
Reconstitution: Aqueous buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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