"Huwentoxin-IV" Related Products

Synthetic Huwentoxin-IV

Cat.No.: TOXPP-526S
Product Overview: This product is a selective blocker with the formula of C174H277N51O52S6.
Description: Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively ontetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronalvoltage-gated sodium channel subtype hNav1.7 (SCN9A, IC50is 26 nM), rNav1.2 (SCN2A, IC50is 150 nM), andrNav1.3 (SCN3A, IC50is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50is > 10 µM).Huwentoxin IVinhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4107.20 Da
Protein length: 35
AA Sequence: AA sequence: Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Lys-Leu-Val-Cys24-Ser-Arg-Lys-Thr-Arg-Trp-Cys31-Lys-Tyr-Gln-Ile-NH2
Disulfide Bonds: Cys2-Cys17; Cys9-Cys24; Cys16-Cys31
Purity: > 97 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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