"Obtustatin" Related Products

Synthetic Obtustatin

Cat.No.: TOXPP-586S
Product Overview: This product is a inhibitor of the binding of α1β1 integrin to collagen IV with the formula of C184H284N52O57S8.
Description: Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a potent (IC50= 2 nM) and selective inhibitor of the binding of α1β1 integrin to collagen IV. Contrary to other known disintegrins, it does not contain the classical RGD sequence. Obtustatin does not show inhibitory activity toward other integrins, including α2β1, αIIbβ3, αvβ3, α4β1, α5β1, α6β1, and α9β1, α4β7 integrins.Obtustatin potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4393.13 Da
Protein length: 41
AA Sequence: AA sequence: Cys1-Thr-Thr-Gly-Pro-Cys6-Cys7-Arg-Gln-Cys10-Lys-Leu-Lys-Pro-Ala-Gly-Thr-Thr-Cys19-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys29-Thr-Gly-Lys-Ser-Cys34-Asp-Cys36-Pro-Leu-Tyr-Pro-Gly-OH
Disulfide Bonds: Cys1-Cys10; Cys6-Cys29; Cys7-Cys34; Cys19-Cys36
Purity: > 97 %
Reconstitution: Aqueous buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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