"ProTx-I" Related Products

Synthetic ProTx-I

Cat.No.: TOXPP-521S
Product Overview: This product is a blocker of voltage-gated sodium channels and T-type Cav with the formula of C171H245N53O47S6.
Description: Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channelNav1.8 (IC50= 27 nM) and Nav1.2, Nav1.5 and Nav1.7with IC50values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3987.50 Da
Protein length: 35
AA Sequence: AA sequence: Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-Ser-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys28
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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