"ProTx-II" Related Products

Synthetic ProTx-II

Cat.No.: TOXPP-516S
Product Overview: This product is a Nav1.7 selective blocker with the formula of C168H250N46O41S8.
Description: ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-IIinhibits bothtetrodotoxin-sensitiveandtetrodotoxin-resistantvoltage-gated sodium channels. ProTx-IIinhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav 1.2, Nav 1.5 and Nav 1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. It also acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3826.65 Da
Protein length: 30
AA Sequence: AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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