"ProTx-II-Biotin" Related Products

Synthetic ProTx-II-Biotin

Cat.No.: TOXPP-519S
Product Overview: This product is a selective blocker of Nav1.7 with the formula of C178H254N48O43S9.
Description: ProTx-II (Protoxin-II)is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-IIinhibits both tetrodotoxin-sensitive and tetrodotoxin-resistantchannels. ProTx-IIinhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximately 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C.ProTx-IIalso binds to phospholipids.ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4052.74 Da
Protein length: 30
AA Sequence: AA sequence: Biotin-Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
Purity: > 95 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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