"Tamapin" Related Products

Synthetic Tamapin

Cat.No.: TOXPP-538S
Product Overview: This product is a selective blocker of SK2 (KCa2.2) channels with the formula of C146H237N44O41S6.
Description: Tamapinis a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. Tamapinis amidated at its C-terminal tyrosine residue. Tamapin binds to small conductance Ca2+-activated K+channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apaminor Leiurotoxin-1 (Scyllatoxin), Tamapinis an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50for SK2 channels = 24 pM).
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3459.00 Da
Protein length: 31
AA Sequence: AA sequence: Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Glu-Glu-Cys26-Lys-Cys28-Val-Pro-Tyr-NH2
Disulfide Bonds: Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
Purity: > 97 %
Reconstitution: Water or saline buffer
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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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