Active Recombinant Mouse Cxcl1 Protein (72 aa)
|Product Overview :||Recombinant Mouse Cxcl1 Protein without tag was expressed in E. coli.|
- Gene Information
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|Description :||KC coded by CXCL1 gene at chromosome 5 is approximately 63% identity to that of mouse MIP2. KC is also approximately 60% identical to the human GROs. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.|
|Source :||E. coli|
|Form :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Bio-activity :||Measured by its ability to chemoattract human CXCR2 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 3-15 ng/mL.|
|Molecular Mass :||Approximately 7.8kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.|
|Protein Length :||72|
|AA Sequence :||APIANELRCQCLQTMAGIHLKNIQS LKVLPSGPHCTQTEVIATLKNGREA CLDPEAPLVQKIVQKMLKGVPK|
|Endotoxin :||Less than 1 EU/μg of rMuKC/CXCL1 as determined by LAL method.|
|Purity :||>97% by SDS-PAGE and HPLC analyses.|
|Storage :||This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 to -70 centigrade. Avoid repeated freeze/thaw cycles.|
|Storage Buffer :||Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.|
|Reconstitution :||We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 centigrade. Further dilutions should be made in appropriate buffered solutions.|
|Gene Name :||Cxcl1 chemokine (C-X-C motif) ligand 1 [ Mus musculus ]|
|Official Symbol :||Cxcl1|
|Synonyms :||CXCL1; chemokine (C-X-C motif) ligand 1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1;|
|Gene ID :||14825|
|mRNA Refseq :||NM_008176|
|Protein Refseq :||NP_032202|
|UniProt ID :||P12850|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
Customer Reviews (3)Write a review
Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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