For glioblastoma, immunotherapy faces a particular challenge—the blood-brain barrier blocks T cells from entering the brain to prevent brain inflammation that can be life-threatening. This “protective measure” is beneficial under normal conditions, but it prevents T cells from reaching the glioblastoma, leaving immunotherapy useless. On September 5th, Nature published an article entitled “A homing system targets therapeutic T cells to brain cancer”, which reveals a new solution from a…
Month: October 2018
PCGF5 Is Required for Neural Differentiation of Embryonic Stem Cells
Researcher Yao Hongjie from the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research report entitled “PCGF5 is required for neural differentiation of embryonic stem cells” on Nature Communications. This work reveals the molecular mechanism by which polycomb PCGF5 regulates the differentiation of embryonic stem cells into neural precursor cells. Epigenetic modification plays an important role in maintaining stem cell characteristics and cell fate transformation….