Most organisms need oxygen to grow and develop, even cancerous tumors. That’s why in the absence of oxygen, tumors can easily grow new blood vessels, creating a new lifeline for survival. In a new study, researchers from Scripps Institute and Nankai University in China have pinpointed the molecular mechanisms that make this happen, and provided scientific insights, making it possible to develop drugs that help kill tumors and prevent…
Month: January 2021
Protein ABCB1 Warps and Squeezes Make Cancer Resistant
In 1986, Kazumitsu Ueda, a Japanese cell biochemist, discovered that a protein called ABCB1 can transport a variety of chemotherapy drugs from some cancer cells, making them resistant to treatment. How it did this has been a mystery for the past 35 years. Now, Ueda and its team published a review article entitled “ABCB1 / mdr1 / P-GP employees an ATP-dependent twist- and -squeeze mechanism to export hydrophobic drugs” in…
New Research Reveals the Mutation of Cholesterol Transporter ABCA13 Associated with Schizophrenia
Scientists have long suspected that the mutation of cholesterol transporter ABCA13 in cells is related to mental illness, but it is difficult to prove this, and it is difficult to determine how it occurs. Now, in a new study, researchers from Kyoto University and other research institutions in Japan have provided evidence that mice with ABCA13 protein damage exhibit characteristic behavior of schizophrenia. They studied the function of ABCA13 and…