New Co-stimulatory Signal Enables CAR-T to Show Its Potential in the Treatment of Solid Tumors

Chimeric antigen receptor (CAR) expressing T cells (CAR-T therapy) is one of the major breakthroughs in the field of cancer treatment in recent years, and has achieved excellent results in the treatment of blood cancer. CAR is like a “GPS navigation system” for T cells, so that T cells can quickly locate tumor cells that are good at camouflage, so as to find and kill them. So far, two CAR-T…

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AIM2 Can Regulate the Normal Function of T Cells and Play a Key Role in Reducing Autoimmune Diseases

Many of the molecules in our body help our immune system stay healthy without overreacting to cause problems for our immune cells, such as autoimmune diseases. There’s a molecule called AIM2 that’s part of the innate immune system that fights pathogens and keeps you healthy. However, little is known about the function of AIM2 in T cell adaptive immunity, which is an immune defense against specific pathogens and health problems…

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