Regulatory T (Treg) cells play an important role in the establishment and maintenance of immune tolerance. Most Treg cells express CD25 molecule, which has a high affinity with IL-2. After activation of CD25, it signals by inducing the activation of transcription factor STAT5. IL-2 plays a central role in many aspects of Treg cell biology. In addition to TCR signaling, IL-2 – STAT5 is also required to induce Foxp3…
Month: April 2021
Inhibition of TMEM16 Can Effectively Block the Production of Syncytia Induced by SARS-CoV-2 Infection
Since the outbreak of COVID-19, it still seriously affects our lives. Therefore, the research on the pathogenesis of COVID19 and the development of related drugs will help to alleviate the epidemic situation and help to make our lives return to normal as soon as possible. Previous studies have shown that COVID19 is a disease with unique characteristics, including pulmonary thrombosis, frequent diarrhea, abnormal activation of inflammatory response and alveolar edema,…
Targeted Nucleotide Rescue Factor DNPH1 Can Improve the Sensitivity of Cancer Cells to PARP Inhibitors
Mutations in BRCA1 or BRCA2 tumor suppressor genes increase the risk of breast and ovarian cancer. In clinical practice, these cancer patients often receive targeted poly ADP ribose polymerase (PARP) inhibitors treatment. According to a recent study published in the journal Science, Stephen C. West from the Francis Crick Institute in the UK showed that inhibition of DNPH1, a protein that eliminates the cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, enhances the…