CDK4 – a master regulator of the cell cycle

The mammalian cell cycle can be divided into four stages, namely Gap 1 (G1 stage), Synthesis (S stage), Gap 2 (G2 stage), and Mitosis (M stage). Its sequence and time are crucial for the accurate transmission of genetic information. Therefore, some biochemical pathways have evolved to ensure that the initiation of a specific cell cycle event depends on the accurate completion of another event. These biochemical pathways are called “checkpoints”….

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Occluding the ACE2 receptor, renders all mutants incapable of infection!

With successive waves of uncapping, enhancing disease resistance has become one of the most important things at present. Vaccines are the most effective medicines to fight the coronavirus at the moment, and intensified vaccination is also a more desirable method.   However, the Omicron virus strain has evolved an extreme ability to infect, and it is not realistic to hope for a vaccine to eliminate the infection. On the other…

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Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis

Leukemia is a highly aggressive hematological malignancy characterized by extensive molecular changes that affect clinical outcomes and provide potential drug development targets. However, the emergence of chemotherapy resistance obviously hinders the effect of chemotherapy and indicates a poor prognosis. About 15% – 30% of leukemia patients are resistant to chemotherapy, and 60% – 80% of patients with complete remission inevitably relapse and succumb to the disease. Therefore, it is very…

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TRPC can significantly regulate the pathogenesis of endotoxemia

Recently, Professor Cao Wei’s team from the School of Chemistry and Pharmacy of Northwest Agriculture and Forestry University published a paper entitled “TRPC channels blockade organisms endotoxic cardiac dysfunction by hamming intelligent inflammation and Ca2+ leakage” in Nature Communications.   This study revealed that the classical transient receptor potential channel (TRPC) subtypes 1 and 6 can significantly regulate the cardiac inflammatory cascade reaction induced by endotoxin, thus playing a key…

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