Because of the expansion and persistence of CAR-T cells, patients receiving CAR-T cells rich in memory T cells tend to have better disease control. Human memory T cells, including stem cell-like CD8+memory T cell progenitors, will become functional stem cell-like T cells (TSTEM) or dysfunctional T group cells (TPEX). Recently, a research report entitled “T STEM like CAR-T cells exhibit improved persistence and transformer control compared with conventional CAR-T cells…
Month: April 2023
PROTAC R&D to Achieve the Latest Progress
Recently, the Li Zigang/Yin Feng research group at the Shenzhen Graduate School of Peking University published a research paper titled “Targeted biomolecule regulation platform: a Split and Mix PROTAC approach” in the Journal of the American Chemical Society, reporting peptide self-assembly formed Split and Mix PROTAC (SM PROTAC), which achieved significant degradation effects on multiple targets, such as ERα, EGFR, MEK1/2, BRD2/4, CDK4/6, AR, BCR-ABL, etc. Targeted protein degradation…
Discovering an Autoimmune Inflammatory Disease Induced by LYN Gene Mutation
Scientists from institutions such as the National Institute of Allergy and Infectious Diseases in the United States have identified an autoimmune disease induced by mutations in the LYN gene, which is an important regulator of the body’s immune response in both healthy and diseased states. Neutrophilic inflammation is a hallmark of the occurrence of many monogenic autoimmune diseases. Currently, researchers are not very clear about the pathological mechanisms that…
Special Protein FAM193A with Novel Anti-Tumor Activity
Scientists from institutions such as the Anschutz School of Medicine at the University of Colorado have discovered and characterized a specific protein that is primarily involved in the specific mechanisms that inhibit the progression of different types of tumors. Understanding how cancer occurs is crucial for designing effective personalized cancer therapies. For many years, researchers have known that cancer begins with mutations in certain types of genes, one of…